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    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Novel 3D Approach to Model Non-Alcoholic Fatty Liver Disease using human Pluripotent Stem Cells

    Carola Maria Morell, Samantha Grace Tilson ... Ludovic Vallier
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Cell Biology
    2. Developmental Biology

    Kap-β2/Transportin mediates β-catenin nuclear transport in Wnt signaling

    Woong Y Hwang, Valentyna Kostiuk ... Mustafa K Khokha
    β-catenin, a key effector of the Wnt signaling pathway, is transported into the nucleus via a direct interaction between its PY-NLS and TNPO1 offering new potential targets for cancer therapeutics.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    The cyanobacterial circadian clock follows midday in vivo and in vitro

    Eugene Leypunskiy, Jenny Lin ... Michael J Rust
    The cyanobacterial core clock tracks midday regardless of day length, which can be understood in terms of a model for how the environment alters the clock limit cycle.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Evolutionary trends of alternative splicing

    Rebeca de la Fuente, Wladimiro Díaz-Villanueva ... Andrés Moya
    Not revised
    Reviewed Preprint v1
    • Important
    • Inadequate
    1. Cell Biology
    2. Plant Biology

    Parallel global profiling of plant TOR dynamics reveals a conserved role for LARP1 in translation

    M Regina Scarpin, Samuel Leiboff, Jacob O Brunkard
    Plants and humans use a shared mechanism, the eukaryotic metabolic sensor TARGET OF RAPAMYCIN protein kinase and its substrate, an RNA-binding protein called LARP1, to coordinate post-transcriptional gene expression.
    1. Evolutionary Biology

    Destructive disinfection of infected brood prevents systemic disease spread in ant colonies

    Christopher D Pull, Line V Ugelvig ... Sylvia Cremer
    Upon detecting a fatal infection using chemical cues, ants puncture the cuticle of sick brood and inject antimicrobial poison that disrupts the pathogen's life cycle and prevents it from reproducing, thus protecting the colony from disease.
    1. Immunology and Inflammation
    2. Neuroscience

    Sensing the world and its dangers: An evolutionary perspective in neuroimmunology

    Aurora Kraus, Katherine M Buckley, Irene Salinas
    The investigation of neuroimmunology in non-model organisms is critical to diversify the field and identify primordial principles that govern neuroimmune communication across taxa.
    1. Physics of Living Systems

    A microfluidic device for inferring metabolic landscapes in yeast monolayer colonies

    Zoran S Marinkovic, Clément Vulin ... Pascal Hersen
    Metabolic gradients underlie gene expression patterns within spatially controlled expanding 2D microbial colonies.
    1. Developmental Biology
    2. Plant Biology

    Epigenetic reprogramming rewires transcription during the alternation of generations in Arabidopsis

    Michael Borg, Ranjith K Papareddy ... Frédéric Berger
    Epigenetic reprogramming of the distinct repressive marks H3K27me3 or H3K9me2 guides the transition between the haploid and diploid life forms that encompass the life cycle of land plants.
    1. Cell Biology
    2. Genetics and Genomics

    Spatial transcriptomic and single-nucleus analysis reveals heterogeneity in a gigantic single-celled syncytium

    Tobias Gerber, Cristina Loureiro ... J Gray Camp
    Nuclei of the true slime mold Physarum polycephalum are continuously shuttled within the cytoplasmic flow across the gigantic syncytium, yet Physarum can establish and maintain gene expression heterogeneity between different structures of the organism.