946 results found
    1. Developmental Biology
    2. Evolutionary Biology

    A distinct cardiopharyngeal mesoderm genetic hierarchy establishes antero-posterior patterning of esophagus striated muscle

    Glenda Comai et al.
    Tbx1-Isl1-Met defines a unique genetic hierarchy that regulates esophagus myogenesis and patterning in the mouse.
    1. Neuroscience

    RIM-BP2 primes synaptic vesicles via recruitment of Munc13-1 at hippocampal mossy fiber synapses

    Marisa M Brockmann et al.
    The active zone scaffold protein RIM-BP2 performs distinct functions in vesicle release at two hippocampal synapses, providing insights on how synapses express diversity in release properties.
    1. Cell Biology
    2. Plant Biology

    Two mechanisms regulate directional cell growth in Arabidopsis lateral roots

    Charlotte Kirchhelle et al.
    In lateral roots, cells employ a novel pathway to cell edges to control directional growth, which acts independently of the leading paradigm of oriented deposition of cellulose microfibrils at faces.
    1. Neuroscience

    Evolution of neuronal anatomy and circuitry in two highly divergent nematode species

    Ray L Hong et al.
    The substrate for evolutionary divergence does not lie in changes in neuronal cell number or targeting, but rather in sensory perception and synaptic partner choice within invariant, prepatterned neuronal processes.
    1. Cell Biology

    A critical role of VMP1 in lipoprotein secretion

    Hideaki Morishita et al.
    The ER transmembrane protein VMP1 is important for release of lipoproteins from the ER membrane into the ER lumen for secretion.
    1. Genetics and Genomics
    2. Neuroscience

    Learning is enhanced by tailoring instruction to individual genetic differences

    David G Mets, Michael S Brainard
    Tailoring instructive experience to individual genetic biases improves vocal learning outcomes across genetic backgrounds in the Bengalese finch.
    1. Neuroscience

    Human motor fatigability as evoked by repetitive movements results from a gradual breakdown of surround inhibition

    Marc Bächinger et al.
    Motor fatigability is associated with a decrease in inhibition throughout the motor network, suggesting that selective inhibitory control is a key mechanism to maintain motor efficiency during repetitive movements.
    1. Developmental Biology
    2. Evolutionary Biology

    The alternative regenerative strategy of bearded dragon unveils the key processes underlying vertebrate tooth renewal

    Lotta Salomies et al.
    Analysis of bearded dragon model reveals a novel tooth replacement strategy that demonstrates the critical importance of epithelial patterning, cell migration, and putative stem cell functional specialization in tissue regeneration.
    1. Cell Biology

    Proteostasis collapse, a hallmark of aging, hinders the chaperone-Start network and arrests cells in G1

    David F Moreno et al.
    Cells accumulate damaged proteins during aging and, by compromising the function of chaperones in folding newly synthesized G1 cyclins, proteostasis breakdown inhibits cell-cycle entry and drives yeast cells into senescence.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Heparan sulfates are critical regulators of the inhibitory megakaryocyte-platelet receptor G6b-B

    Timo Vögtle et al.
    Heparan sulfates in the vessel wall bind and regulate signaling from the megakaryocyte/platelet-specific inhibitory receptor G6b-B, a critical regulator of platelet homeostasis.

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