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    1. Developmental Biology
    2. Evolutionary Biology

    Metamorphosis: The making of a maggot brain

    Andreas S Thum, Bertram Gerber
    The way neurons in the brain rewire in larvae as they turn to adult fruit flies sheds light on how complete metamorphosis was ‘invented’ over the course of evolution.
    Version of Record
    Insight
    1. Neuroscience

    Cadherin preserves cohesion across involuting tissues during C. elegans neurulation

    Kristopher M Barnes, Li Fan ... Zhirong Bao
    A coordinated tissue movement during C. elegans central nervous system internalization reveals a novel role for HMR-1/cadherin in maintaining cohesion, and extends the concept of neurulation beyond vertebrates.
    1. Evolutionary Biology
    2. Neuroscience

    Diversity and evolution of cerebellar folding in mammals

    Katja Heuer, Nicolas Traut ... Roberto Toro
    A computational neuroanatomy analysis of cerebellar and cerebral folding in 56 mammalian species reveals groups of highly variable 'diverse' phenotypes, and strongly conserved 'stable' phenotypes, providing new insights into the diversity, evolution, and influence of cortical folding on brain organisation.
    1. Evolutionary Biology

    Novel neuroanatomical integration and scaling define avian brain shape evolution and development

    Akinobu Watanabe, Amy M Balanoff ... Mark A Norell
    More integrated brains in crown birds evolved through a mosaic assembly of new evolutionary and developmental dynamics across neuroanatomical regions that occurred along the dinosaur-bird transition.
    1. Evolutionary Biology
    2. Neuroscience

    A brain-wide analysis maps structural evolution to distinct anatomical module

    Robert A Kozol, Andrew J Conith ... Erik R Duboue
    Genetic analyses reveal that neuroanatomical areas that are developmentally related co-evolve with one another.
    1. Genetics and Genomics
    2. Evolutionary Biology

    Regulatory and coding sequences of TRNP1 co-evolve with brain size and cortical folding in mammals

    Zane Kliesmete, Lucas Esteban Wange ... Wolfgang Enard
    Combining phylogenetic and functional approaches, it is shown that the protein sequence, the proliferative activity, and a regulatory element of TRNP1 co-evolve with brain size and folding.
    1. Neuroscience

    Cross-species alignment along the chronological axis reveals evolutionary effect on structural development of the human brain

    Yue Li, Qinyao Sun ... Jiaojian Wang
    A novel methodological strategy based on machine learning has been developed to study brain evolution across species.
    1. Neuroscience

    Point of View: Predictive regulation and human design

    Peter Sterling
    Why does the human regulatory system, which evolution tuned for small satisfactions, now constantly demand 'more'?
    1. Ecology
    2. Genetics and Genomics

    Individual differences in honey bee behavior enabled by plasticity in brain gene regulatory networks

    Beryl M Jones, Vikyath D Rao ... Gene E Robinson
    Integration of automatic behavioral tracking with brain molecular profiling reveals the role of gene regulatory network plasticity in the regulation of behavioral phenotypes.
    1. Evolutionary Biology
    2. Neuroscience

    A cerebellar substrate for cognition evolved multiple times independently in mammals

    Jeroen B Smaers, Alan H Turner ... Chet C Sherwood
    Multiple independent directional selection events on a neural substrate that underpins domain-general associative abilities partly explains independent occurrences of complex behavior in different lineages of mammals.