The direct interaction of R-type Ca2+ channel Cav2.3 and GABAB receptor auxiliary subunits in the active zone of medial habenula terminals scales synaptic strength independent of GABAB receptor activation.
Differences in the lipid solvation energetics of associated and dissociated states is a primary driving force for membrane protein oligomerization, presenting a molecular mechanism for lipid regulation in biology.
Developing T cells whose TCRs have relatively low reactivity experience very brief TCR signaling events, experience delayed positive selection, and retaina preselection gene expression signature as they mature.
Structure modeling, site-directed mutagenesis, and current recordings revealed the mechanism by which stabilization of voltage sensors in the resting and activated states determines the gating properties of the CaV1.1 calcium channel.
Identified as a binding factor of transcription factor MYRF, the LRR-TM protein PAN-1 promotes the cell-membrane localization and nuclear translocation of MYRF, which drives synaptic rewiring in Caenorhabditis elegans.