1,899 results found
    1. Developmental Biology
    2. Evolutionary Biology

    Evolutionary emergence of Hairless as a novel component of the Notch signaling pathway

    Steven W Miller et al.
    Hairless emerged as an evolutionarily novel regulatory protein that replaced an ancestral paradigm of direct co-repressor recruitment by Suppressor of Hairless, its partner transcription factor in the Notch signaling pathway.
    1. Developmental Biology
    2. Evolutionary Biology

    Evolutionary expansion of apical extracellular matrix is required for the elongation of cells in a novel structure

    Sarah Jacquelyn Smith et al.
    A new morphological structure evolved through extreme changes in cell height requires novel connections to an extracellular matrix network, which predates the origin of structure.
    1. Evolutionary Biology
    2. Neuroscience

    Shore crabs reveal novel evolutionary attributes of the mushroom body

    Nicholas Strausfeld, Marcel E Sayre
    Dramatic phenotypic divergence of crustacean mushroom bodies map to phylogenetic lineages, thereby offering unexplored opportunities for relating divergent cognitive centers to different ecologies and behavioral repertoires required to negotiate them.
    1. Developmental Biology
    2. Genetics and Genomics

    The genome sequence of the colonial chordate, Botryllus schlosseri

    Ayelet Voskoboynik et al.
    The Botryllus schlosseri genome yields insights into the evolution of hematopoiesis.
    1. Ecology
    2. Evolutionary Biology

    Variable opportunities for outcrossing result in hotspots of novel genetic variation in a pathogen metapopulation

    Anna-Liisa Laine et al.
    In natural pathogen populations opportunities for sexual outcrossing vary, leading to spatial variation in genetic diversity and between-season survival.
    1. Evolutionary Biology

    Genes associated with ant social behavior show distinct transcriptional and evolutionary patterns

    Alexander S Mikheyev, Timothy A Linksvayer
    Genes associated with age-based division of labor in ants exist in distinct regulatory and evolutionary contexts; genes up-regulated in young nurses are loosely connected and rapidly evolving while genes up-regulated in old foragers are highly connected and conserved.
    1. Evolutionary Biology
    2. Neuroscience

    Echinoderms provide missing link in the evolution of PrRP/sNPF-type neuropeptide signalling

    Luis Alfonso Yañez-Guerra et al.
    Discovery of a novel neuropeptide signalling system in a deuterostome invertebrate reveals the evolutionary origin of prolactin-releasing peptide and its relationship with neuropeptides in protostome invertebrates.
    1. Structural Biology and Molecular Biophysics

    Casposase structure and the mechanistic link between DNA transposition and spacer acquisition by CRISPR-Cas

    Alison B Hickman et al.
    The tetrameric structure of a casposase bound to DNA and its biochemical properties show how a transposase could have evolved to perform CRISPR-Cas spacer acquisition.
    1. Evolutionary Biology
    2. Genetics and Genomics

    A putative origin of the insect chemosensory receptor superfamily in the last common eukaryotic ancestor

    Richard Benton et al.
    Comparative genomics and three-dimensional protein modelling identify homologs of insect chemosensory receptors in unicellular eukaryotes and plants.
    1. Evolutionary Biology

    Subterranean mammals show convergent regression in ocular genes and enhancers, along with adaptation to tunneling

    Raghavendran Partha et al.
    Repeated evolution of eye regression in subterranean mammals helps identify genes and regulatory elements involved in visual perception and development of the eye, and predicts candidate sequences with a potential role in ocular disorders.

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