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    1. Developmental Biology

    A lncRNA fine tunes the dynamics of a cell state transition involving Lin28, let-7 and de novo DNA methylation

    Meng Amy Li et al.
    A novel lncRNA (Ephemeron) is connected to known post-transcriptional and epigenetic regulators as part of an integrated machinery, which controls the timely exit from the naïve state of mouse embryonic stem cells.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Two-step membrane binding by the bacterial SRP receptor enable efficient and accurate Co-translational protein targeting

    Yu-Hsien Hwang Fu et al.
    Single molecule microscopy combined with biochemical analyses show that a two-step lipid-binding mechanism of the SRP receptor balances the trade-off between speed and specificity during co-translational protein targeting.
    1. Developmental Biology

    Lunatic fringe-mediated Notch signaling regulates adult hippocampal neural stem cell maintenance

    Fatih Semerci et al.
    In adult mouse hippocampus, neural stem cell and their progeny communicate via Lunatic Fringe mediated Notch signaling to regulate stem cell quiescence, division, and fate.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    9Å structure of the COPI coat reveals that the Arf1 GTPase occupies two contrasting molecular environments

    Svetlana O Dodonova et al.
    A molecular model of the assembled COPI coat, determined by cryo-electron tomography of an in vitro reconstituted budding reaction, reveals details of interactions mediating coat assembly and shows the binding site of ArfGAP2.
    1. Neuroscience

    Inhibitory peptidergic modulation of C. elegans serotonin neurons is gated by T-type calcium channels

    Kara E Zang et al.
    Genetic analysis of how neuropeptides control C. elegans reproductive behavior shows how T-type calcium channels engage and disengage target neurons from these critical regulators of neural circuits and behavior.
    1. Developmental Biology

    DNA methylation and gene expression changes derived from assisted reproductive technologies can be decreased by reproductive fluids

    Sebastian Canovas et al.
    Reproductive fluids help the correct establishment of some epigenetic marks and gene expression in preimplantation pig embryos.
    1. Biochemistry and Chemical Biology

    The ribosomal protein Asc1/RACK1 is required for efficient translation of short mRNAs

    Mary K Thompson et al.
    Asc1/RACK1 promotes the translation of mRNAs associated with the translational closed loop complex, which have short open reading frames and encode proteins required for core metabolic processes.
    1. Developmental Biology

    Ancient origin of lubricated joints in bony vertebrates

    Amjad Askary et al.
    Zebrafish have lubricated joints similar to ours and are a tractable model for arthritis research.
    1. Plant Biology
    2. Evolutionary Biology

    Herbivory-induced volatiles function as defenses increasing fitness of the native plant Nicotiana attenuata in nature

    Meredith C Schuman et al.
    A 2-year field study has demonstrated that volatile compounds produced by plants when they are attacked by herbivores act as defenses by attracting predators to the herbivores and increasing the reproduction of the plants.
    1. Human Biology and Medicine

    ANGPTL4 mediates shuttling of lipid fuel to brown adipose tissue during sustained cold exposure

    Wieneke Dijk et al.
    During sustained cold exposure, lipid fuel is specifically directed towards brown adipose tissue, but not white adipose tissue, via cold-induced regulation of Angiopoietin-like 4 (ANGPTL4).