60 results found
    1. Computational and Systems Biology
    2. Developmental Biology

    Modularity, criticality, and evolvability of a developmental gene regulatory network

    Berta Verd et al.
    A new approach focusing on dynamic modularity helps overcome traditional challenges detecting modularity in complex adaptive systems.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    The inherent mutational tolerance and antigenic evolvability of influenza hemagglutinin

    Bargavi Thyagarajan, Jesse D Bloom
    Deep mutational scanning was used to comprehensively quantify the effects of mutations to influenza hemagglutinin and shows that the virus possesses a high inherent mutational tolerance at key antigenic sites.
    1. Genetics and Genomics

    Buffered Qualitative Stability explains the robustness and evolvability of transcriptional networks

    Luca Albergante et al.
    The theory of Buffered Qualitative Stability uses the importance of biological robustness to explain many features of gene regulatory networks in a wide range of organisms, and has implications for diverse biological phenomena including the ability of bacteria and cancer cells to ‘loosen’ their robustness and hence evade treatment.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Principles of dengue virus evolvability derived from genotype-fitness maps in human and mosquito cells

    Patrick T Dolan et al.
    Distinct selective landscapes in mosquito and human cells shape dengue virus genetic diversity and highlight mechanisms of host adaptation in arboviruses.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Cryptic genetic variation shapes the adaptive evolutionary potential of enzymes

    Florian Baier et al.
    Genetic change among enzyme orthologous with similar phenotypic properties can cause substantial differences in evolutionary response to a new enzyme function in terms of their molecular and fitness outcomes.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Distinct functional determinants of influenza hemagglutinin-mediated membrane fusion

    Tijana Ivanovic, Stephen C Harrison
    The mechanism of membrane-fusion catalysis in influenza viral infection of target cells is robust against the presence of a large fraction of non-productive viral fusion proteins.
    1. Evolutionary Biology

    Phenotypic plasticity as an adaptation to a functional trade-off

    Xiao Yi, Antony M Dean
    A plastic behavior in Escherichia coli is enabled by a single amino acid replacement in adaption to changing environments.
    1. Microbiology and Infectious Disease

    Adaptive tuning of mutation rates allows fast response to lethal stress in Escherichia coli

    Toon Swings et al.
    Population mutation rates are highly flexible and evolvable under extreme stress conditions, matching changes in selective pressure to avoid extinction of the entire population.
    1. Structural Biology and Molecular Biophysics

    Structures of two aptamers with differing ligand specificity reveal ruggedness in the functional landscape of RNA

    Andrew John Knappenberger et al.
    RNA aptamers that are closely related and share a common scaffold can readily adapt to recognize new ligands through changes in just a few nucleotides.
    1. Evolutionary Biology

    RNA chaperones buffer deleterious mutations in E. coli

    Marina Rudan et al.
    The overexpression of RNA chaperones, including several DEAD box RNA helicases, enhances the fitness of mutationally compromised E. coli strains.

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