299 results found
    1. Computational and Systems Biology
    2. Ecology

    Trade-off shapes diversity in eco-evolutionary dynamics

    Farnoush Farahpour, Mohammadkarim Saeedghalati ... Daniel Hoffmann
    In a minimalistic, generic model of competitive communities in which evolution is constrained by life-history trade-offs, stable biodiversity emerges with species adapted to different functional niches.
    1. Evolutionary Biology

    Topological constraints in early multicellularity favor reproductive division of labor

    David Yanni, Shane Jacobeen ... Peter J Yunker
    Mathematical modeling shows that reproductive specialization is strongly favored in sparse networks of cellular interactions that reflect the morphology of early multicellular organisms, even when benefits of specialization are saturating.
    1. Neuroscience

    Sensory-memory interactions via modular structure explain errors in visual working memory

    Jun Yang, Hanqi Zhang, Sukbin Lim
    Two-module networks, combining sensory efficient coding and attractor dynamics for memory maintenance, effectively explain working memory error patterns, highlighting the role of sensory-memory interactions in continuously shaping memory representations.
    1. Evolutionary Biology

    Genes associated with ant social behavior show distinct transcriptional and evolutionary patterns

    Alexander S Mikheyev, Timothy A Linksvayer
    Genes associated with age-based division of labor in ants exist in distinct regulatory and evolutionary contexts; genes up-regulated in young nurses are loosely connected and rapidly evolving while genes up-regulated in old foragers are highly connected and conserved.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Functional trade-offs and environmental variation shaped ancient trajectories in the evolution of dim-light vision

    Gianni M Castiglione, Belinda SW Chang
    The evolution of the light-sensitive visual pigment rhodopsin involved functional tradeoffs that may have sacrificed rod photosensitivity for active-state protein stability to mitigate phototoxicity in tetrapods, but not in fishes.
    1. Computational and Systems Biology
    2. Developmental Biology

    A repressor-decay timer for robust temporal patterning in embryonic Drosophila neuroblast lineages

    Inna Averbukh, Sen-Lin Lai ... Naama Barkai
    The demand for robust performance distinguishes the mechanism which progresses the biological timer acting within neural progenitors to determine neuronal fates in the Drosophila embryo.
    1. Computational and Systems Biology
    2. Developmental Biology

    Modularity, criticality, and evolvability of a developmental gene regulatory network

    Berta Verd, Nicholas AM Monk, Johannes Jaeger
    A new approach focusing on dynamic modularity helps overcome traditional challenges detecting modularity in complex adaptive systems.
    1. Epidemiology and Global Health

    Projected resurgence of COVID-19 in the United States in July—December 2021 resulting from the increased transmissibility of the Delta variant and faltering vaccination

    Shaun Truelove, Claire P Smith ... Cecile Viboud
    Multi-model ensembling projected that the Delta variant would lead to a substantial COVID-19 resurgence in the US, with higher vaccination uptake being a critical factor for limiting transmission and impact between states.
    1. Computational and Systems Biology

    Evolution of cell size control is canalized towards adders or sizers by cell cycle structure and selective pressures

    Felix Proulx-Giraldeau, Jan M Skotheim, Paul François
    An evolutionary algorithm is used to build gene networks implementing cell size control, and suggests multiple ways for evolution to first build sizers and turn them into adders depending on evolutionary constraints.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    Trans regulation of an odorant binding protein by a proto-Y chromosome affects male courtship in house fly

    Pablo J Delclos, Kiran Adhikari ... Richard Meisel
    An integrative approach is used to identify a mechanism by which the fitness effects of Y chromosomes can manifest via trans effects on autosomal genes, through their effects on male courtship and other sexually selected traits.

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