Malaria parasites have simplified and adapted their mitochondrial metabolism to lack fatty acid synthesis but retain an unusual acyl carrier protein required for stability of the core iron-sulfur cluster biogenesis complex.
A previously uncharacterized type of bivalent chromatin plays an important role controlling the timely induction of genes involved in making a potent defense metabolite upon a pathogen signal in Arabidopsis.
Acetylcholine, released from cholinergic fibers originating from the medial septum, shapes social memory, and controls the CA2 hippocampal circuit via nicotinic receptors localized on GABAergic interneurons.
Fluorescence fluctuation spectroscopy is implemented for detection of up to four molecular species, allowing users to quantify molecular interactions and stoichiometry of multicomponent complexes in live cells, in a wide range of biological processes, from membrane signaling to viral assembly.
Somatic stem and niche cells in the Drosophila ovary develop from common precursors through regulated proliferative expansion, followed by acquisition of position-specific behaviors, rather than through rigid early specification events.
Retinal pigment epithelium flattening is an efficient solution adopted by the fast-developing zebrafish to enable folding of the eye primordia, which contrasts with the proliferation-based mechanism used by amniotes.
A parsimonious biophysical model correctly predicts the conserved expression stoichiometry of core bacterial mRNA translation factors, providing intuitive and quantitative design principles for in vivo pathway construction.
Lesions to the anterior-medio-dorsal thalamus cause widespread behavioral impairments across multiple cognitive domains, suggesting that thalamic hubs are critical for interconnecting diverse cognitive processes.