Delayed inhibition precisely balances excitation from arbitrary combinations of CA3 neurons and controls the gain of CA1 output by reducing inhibitory delay with increasing excitation.
Computational modeling and analysis of mouse neural population data finds that the excitation/inhibition imbalance theory of brain disorders is too limited to account for key changes in neural activity statistics.
During development, the Xenopus brain improves its ability to discern specific time intervals between sensory inputs of different modalities via the maturation of inhibitory circuits.
Inhibitory circuits in the olfactory bulb can amplify or suppress sensory inputs over a wide range of intensities to generate robust mitral cell output.
Ketamine, an NMDA receptor antagonist and experimental model for schizophrenia, produces decision-making deficits in monkeys, which are predicted by a lowering of cortical excitation-inhibition balance in a spiking circuit model.
The formation and refinement of prediction error circuits relies on an experience-dependent balance of excitation and inhibition in canonical microcircuits.
The composition of inhibitory and excitatory synaptic inputs to the apical dendrites of pyramidal cells in mouse cortex is specific to the type of pyramidal cells.
