838 results found
    1. Neuroscience

    Neuronal complexity is attenuated in preclinical models of migraine and restored by HDAC6 inhibition

    Zachariah Bertels et al.
    In models of chronic migraine, neuronal complexity is diminished in head-pain processing regions but restored through HDAC6 inhibition, which increases tubulin acetylation and cytoskeletal flexibility, and CGRP receptor blockade.
    1. Neuroscience

    GABAB receptor auxiliary subunits modulate Cav2.3-mediated release from medial habenula terminals

    Pradeep Bhandari et al.
    The direct interaction of R-type Ca2+ channel Cav2.3 and GABAB receptor auxiliary subunits in the active zone of medial habenula terminals scales synaptic strength independent of GABAB receptor activation.
    1. Neuroscience

    Permeabilization-free en bloc immunohistochemistry for correlative microscopy

    Kara A Fulton, Kevin L Briggman
    Immunohistochemical labeling of antigens deep within mouse brain tissue sections was achieved without the need for lipid permeabilization, thereby preserving tissue ultrastructure and enabling correlative light and electron microscopy studies.
    1. Neuroscience

    Variability in the Munc13-1 content of excitatory release sites

    Maria Rita Karlocai et al.
    Different numbers of Munc13-1 molecules build up the specialized regions of the presynaptic plasma membrane called the release sites.
    1. Neuroscience

    GABAA presynaptic inhibition regulates the gain and kinetics of retinal output neurons

    Jenna Nagy et al.
    Elimination of GABAA receptors from the axon terminals of specific retinal bipolar cell types alters the sensitivity and kinetics of retinal output.
    1. Developmental Biology
    2. Neuroscience

    Linking mPFC circuit maturation to the developmental regulation of emotional memory and cognitive flexibility

    Cassandra B Klune et al.
    An analysis of recent literature advances novel hypotheses and suggests new experimental approaches in order to build an integrated understanding of prefrontal neural architecture and behavioral repertoires during development.
    1. Developmental Biology
    2. Neuroscience

    Electrical synaptic transmission requires a postsynaptic scaffolding protein

    Abagael M Lasseigne et al.
    A postsynaptic, intracellular, scaffolding protein is necessary to build neuronal gap junctions, revealing an unanticipated complexity of molecular and functional organization of electrical synapses.
    1. Neuroscience

    Rapid recycling of glutamate transporters on the astroglial surface

    Piotr Michaluk et al.
    Rapid membrane turnover is the main 'redeployment' route for the immobile fraction of surface-expressed astroglial glutamate transporters that confine excitatory transmission to the synaptic cleft.
    1. Neuroscience

    Neural effects of propofol-induced unconsciousness and its reversal using thalamic stimulation

    André M Bastos et al.
    Understanding how general anesthesia changes neural dynamics in the cortex and thalamus can lead to its safer use and shed light on the nature of consciousness.
    1. Neuroscience

    Learning excitatory-inhibitory neuronal assemblies in recurrent networks

    Owen Mackwood et al.
    The synaptic structure in mouse V1 is explained by a synergy of homeostatic plasticity in incoming and outgoing synapses of inhibitory interneurons, establishing a stimulus-specific balance of excitation and inhibition.

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