838 results found
    1. Neuroscience

    MEF2C regulates cortical inhibitory and excitatory synapses and behaviors relevant to neurodevelopmental disorders

    Adam J Harrington et al.
    Mice that lack the autism- and schizophrenia-linked gene MEF2C in cortical neurons have an imbalance of excitatory and inhibitory synapses, and impaired social and cognitive abilities.
    1. Neuroscience

    Excitatory and inhibitory synapse reorganization immediately after critical sensory experience in a vocal learner

    Ziqiang Huang et al.
    Sensory acquisition of a motor target is associated with rapid removal of excitatory synapses and with rapid insertion of inhibitory synapses in the main song control area of songbirds.
    1. Neuroscience

    Pathway-specific dysregulation of striatal excitatory synapses by LRRK2 mutations

    Chuyu Chen et al.
    Although human Parkinson's disease is linked to dopamine loss, two distinct mutations in a kinase associated with familial Parkinson's operate downstream, altering excitatory synapses on dopamine-sensing neurons.
    1. Neuroscience

    Presynaptic LRP4 promotes synapse number and function of excitatory CNS neurons

    Timothy J Mosca et al.
    The cell surface receptor LRP4, long recognized for postsynaptic functions, also plays a role as a presynaptic determinant of synapse formation by functioning through a downstream kinase pathway.
    1. Cell Biology
    2. Neuroscience

    Ciliary neuropeptidergic signaling dynamically regulates excitatory synapses in postnatal neocortical pyramidal neurons

    Lauren Tereshko et al.
    Neuropeptidergic signaling via cilia-localized receptors dynamically regulates excitatory synaptic drive in postnatal rat neocortical pyramidal neurons.
    1. Neuroscience

    ELKS controls the pool of readily releasable vesicles at excitatory synapses through its N-terminal coiled-coil domains

    Richard G Held et al.
    The presynaptic active zone protein ELKS provides synapse-specific control of the pool of readily releasable vesicles and release probability.
    1. Neuroscience

    Neuromodulation of excitatory synaptogenesis in striatal development

    Yevgenia Kozorovitskiy et al.
    Protein kinase A regulates the rapid, activity-dependent genesis of excitatory synapses during striatal development.
    1. Neuroscience

    Subcellular sorting of neuregulins controls the assembly of excitatory-inhibitory cortical circuits

    David Exposito-Alonso et al.
    Neuregulins control the integration of specific excitatory and inhibitory synapses through subcellular sorting.
    1. Neuroscience

    Cell-specific gain modulation by synaptically released zinc in cortical circuits of audition

    Charles T Anderson et al.
    Synaptic zinc is a novel modulator of cortical sound processing - a modulator that increases the gain of principal neurons, but reduces the gain of interneurons.
    1. Neuroscience

    Loss of MeCP2 disrupts cell autonomous and autocrine BDNF signaling in mouse glutamatergic neurons

    Charanya Sampathkumar et al.
    In mouse models of Rett syndrome, the impaired cell autonomous BDNF feed forward signaling pathway results in abnormalities in neurite outgrowth and synapse formation in excitatory neurons.

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