530 results found
    1. Cell Biology
    2. Neuroscience

    Speed and segmentation control mechanisms characterized in rhythmically-active circuits created from spinal neurons produced from genetically-tagged embryonic stem cells

    Matthew J Sternfeld et al.
    Stem cell derived ventral-spinal cord excitatory neurons self-assemble into a rhythmically bursting neural network whose speed and intercellular coordination are both instructively modulated by cell-type specific interactions with inhibitory neurons.
    1. Neuroscience

    MEF2C regulates cortical inhibitory and excitatory synapses and behaviors relevant to neurodevelopmental disorders

    Adam J Harrington et al.
    Mice that lack the autism- and schizophrenia-linked gene MEF2C in cortical neurons have an imbalance of excitatory and inhibitory synapses, and impaired social and cognitive abilities.
    1. Genetics and Genomics
    2. Neuroscience

    Gain-of-function mutations in the UNC-2/CaV2α channel lead to excitation-dominant synaptic transmission in Caenorhabditis elegans

    Yung-Chi Huang et al.
    Caenorhabditis elegans studies indicate that gain-of-function mutations in the presynaptic voltage-gated calcium, associated with familial hemiplegic migraine in humans, result in excitatory-inhibitory imbalance in the nervous system.
    1. Neuroscience

    Optimal compensation for neuron loss

    David GT Barrett et al.
    Spiking networks compensate the loss of neurons instantaneously, when restoration of excitatory/inhibitory balance becomes equivalent to restoration of functionality.
    1. Neuroscience

    Computational Neuroscience: Finding patterns in cortical responses

    Alessandro Sanzeni, Mark H Histed
    Simulations predict a paradoxical effect that should be revealed by patterned stimulation of the cortex.
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    1. Neuroscience

    Motor Networks: The Goldilocks zone in neural circuits

    Mark D Humphries
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    1. Developmental Biology
    2. Neuroscience

    Clustered gamma-protocadherins regulate cortical interneuron programmed cell death

    Walter R Mancia Leon et al.
    Pcdhg determine survival of the GABAergic cortical interneuron population that is necessary to establish and maintain proper excitatory to inhibitory balance in the cerebral cortex.
    1. Medicine
    2. Neuroscience

    Autism: Balancing excitation and inhibition in the autistic brain

    Charlotte M Pretzsch, Dorothea L Floris
    A metric called the Hurst exponent could be a useful biomarker for studies exploring brain differences between men and women with autism spectrum disorder.
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    1. Computational and Systems Biology
    2. Neuroscience

    Brain Networks: Modeling breathing rhythms

    Jan-Marino Ramirez, Nathan A Baertsch
    Computational models are helping researchers to understand how certain properties of neurons contribute to respiratory rhythms.
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    1. Neuroscience

    Chronic postnatal chemogenetic activation of forebrain excitatory neurons evokes persistent changes in mood behavior

    Sthitapranjya Pati et al.
    Enhanced Gq-signaling-mediated activation of forebrain excitatory neurons in postnatal life programs enhanced anxiety-, despair- and schizophrenia-like behavior, recapitulating key aspects of the behavioral consequences of early life adversity.

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