1,501 results found
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Single-fluorophore membrane transport activity sensors with dual-emission read-out

    Cindy Ast et al.
    Building on previous work (De Michele et al., 2013), we report the development of dual-emission AmTrac sensors for in vivo analysis of transporter activity.
    1. Structural Biology and Molecular Biophysics

    The primary structural photoresponse of phytochrome proteins captured by a femtosecond X-ray laser

    Elin Claesson et al.
    Time-resolved crystallography provides insight into the photochemical reactions in photoreceptor proteins, explaining the earliest steps of how plants, fungi and bacteria sense red light.
    1. Cell Biology

    The quantitative architecture of centromeric chromatin

    Dani L Bodor et al.
    The number of CENP-A molecules at human centromeres helps to explain how this structure is built and epigenetically inherited.
    1. Structural Biology and Molecular Biophysics

    Nanoscopic anatomy of dynamic multi-protein complexes at membranes resolved by graphene-induced energy transfer

    Nadia Füllbrunn et al.
    The axial organization and dynamics of the HOPS complex at membrane surface are resolved by graphene-induced energy transfer with subnanometer resolution.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Functional genomics of lipid metabolism in the oleaginous yeast Rhodosporidium toruloides

    Samuel T Coradetti et al.
    Using barcoded mutagenesis and a high-throughput genetic screen results in the identification of 150 genes that affect lipid accumulation in a non-model yeast system.
    1. Ecology

    Algal-fungal symbiosis leads to photosynthetic mycelium

    Zhi-Yan Du et al.
    The capacity for symbiosis between photosynthetic microalgae and early diverging lineages fungi was demonstrated with microscopy and stable isotope exchange of carbon and nitrogen.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Photo-switchable tweezers illuminate pore-opening motions of an ATP-gated P2X ion channel

    Chloé Habermacher et al.
    The gating mechanism of trimeric ATP-gated P2X receptors has been explored using photo-switchable cross-linkers, via a versatile strategy that could be applied to other membrane proteins.
    1. Plant Biology

    Photosynthesis without β-carotene

    Pengqi Xu et al.
    Tobacco plants containing xanthophyll astaxanthin show that both photosystems are fully functional in the absence of carotenes, and these pigments are not essential for photosynthesis.
    1. Cancer Biology
    2. Cell Biology

    Human pancreatic cancer cell exosomes, but not human normal cell exosomes, act as an initiator in cell transformation

    Karoliina Stefanius et al.
    Exosomes secreted from pancreatic cancer cells can function as a classic initiator in the multi-step cellular transformation process.
    1. Neuroscience

    Combinatorial programming of human neuronal progenitors using magnetically-guided stoichiometric mRNA delivery

    Sayyed M Azimi et al.
    A technology allows rapid screening of vast numbers of transcriptional factor combinatorials on stem cell programming.

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