Planarians provide evidence for a common evolutionary origin of vertebrate and invertebrate excretory systems and provide a novel experimental model to study human kidney diseases.

PAR-6 and PKC-3/aPKC are essential for postembryonic development of C. elegans and control the organization of non-centrosomal microtubule bundles in the epidermis, likely through recruitment of NOCA-1/Ninein.

Lumen extension in intracellular tubes relies on a molecular pathway involving Rho GTPase signaling, cell polarity, and vesicle-tethering proteins.

Aberrant cytoskeletal intermediate filament networks in the C. elegans intestine are associated with hyperphosphorylated intermediate filament proteins and impact not only intestinal cell structure but have also detrimental consequences for organismal well-being.

Behavioral assays using Caenorhabditis elegans show that a learned pathogen avoidance following intestinal distention requires specific chemosensory neurons and TRPM channels in the intestine and excretory cell.

The SEL-5/AAK1 kinase unexpectedly influences Wnt signalling-dependent processes in a multicellular organism without using its enzymatic activity.

HpBARI is a protein secreted by a parasitic helminth, which binds to and blocks the IL-33 receptor, suppressing IL-33-dependent type 2 immune responses.

A landmark-based cross-modality alignment method robust to variation in landmark sets is applied to annotate an EM time series of Caenorhabditis elegans embryonic development as a community resource.

A single-cell gene expression atlas in a human parasitic nematode provides new insights into the distribution of anthelmintic targets and the origins of secretory molecules with diagnostic and therapeutic potential at the host–parasite interface.