401 results found
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease
    Tropical disease

    Tropical Disease: A Collection of Articles

    Edited by Prabhat Jha et al.
    eLife has published papers on many tropical diseases, including malaria, Ebola, leishmaniases, Dengue and African sleeping sickness.
  1. December 2014

    Episode 16: December 2014

    In this episode we hear about reproducibility, drug resistance, cells without walls, gene transfer, interspecies signalling, and stem cells.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The ER–Golgi intermediate compartment is a key membrane source for the LC3 lipidation step of autophagosome biogenesis

    Liang Ge et al.
    A cell-free biochemical assay for protein lipidation identifies the ER–Golgi intermediate compartment as a key early station in the formation of an autophagosome.
    1. Cell Biology

    GnT1IP-L specifically inhibits MGAT1 in the Golgi via its luminal domain

    Hung-Hsiang Huang et al.
    GnT1IP-L is a membrane bound glycoprotein that interacts with MGAT1 in the Golgi, but not in the endoplasmic reticulum, to regulate complex N-glycan synthesis.
    1. Cell Biology
    2. Neuroscience

    Small molecule induced oligomerization, clustering and clathrin-independent endocytosis of the dopamine transporter

    Tatiana Sorkina et al.
    Dopamine transporter (DAT) interaction with furopyrimidine called AIM-100 in intact cells leads to dramatic oligomerization, nanoclustering and endocytosis of DAT by a novel mechanism coupled to the transporter molecule conformation.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    A new experimental platform facilitates assessment of the transcriptional and chromatin landscapes of aging yeast

    David G Hendrickson et al.
    A new technology for obtaining aged yeast cells helps reveal a striking connection between aging, slow growth, and stress.
    1. Ecology

    Acknowledging selection at sub-organismal levels resolves controversy on pro-cooperation mechanisms

    Wenying Shou
    Building on previous work (Momeni et al., 2013), it is shown that recognizing the hierarchical organization of biological systems resolves the ongoing controversy on pro-cooperation mechanisms.
    1. Cell Biology
    2. Neuroscience

    A dynamin 1-, dynamin 3- and clathrin-independent pathway of synaptic vesicle recycling mediated by bulk endocytosis

    Yumei Wu et al.
    Analysis of neurons that lack the two neuronal dynamins, dynamin 1 and 3, demonstrates a pathway of synaptic vesicle reformation that does not require these two dynamins or clathrin-dependent budding.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    ISG15 counteracts Listeria monocytogenes infection

    Lilliana Radoshevich et al.
    The induction of ISG15 during bacterial infection can be independent of Type I Interferons and leads to an increase in the secretion of cytokines known to be critical for bacterial clearance.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Proteolytic maturation of α2δ represents a checkpoint for activation and neuronal trafficking of latent calcium channels

    Ivan Kadurin et al.
    Multiple roles of the auxiliary calcium channel α2δ subunits require proteolytic cleavage of the precursor protein into α2 and δ.

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