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    1. Neuroscience

    Whole-body connectome of a segmented annelid larva

    Csaba Verasztó, Sanja Jasek ... Gáspár Jékely
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Cell Biology
    2. Evolutionary Biology

    Epidermal threads reveal the origin of hagfish slime

    Yu Zeng, David C Plachetzki ... Douglas Fudge
    The hagfish slime glands, which produce a large volume of defensive slime within 0.4 s by ejecting threads and mucus into seawater, evolved from cells and genes expressed in the skin.
    1. Neuroscience

    Drosophila larval to pupal switch under nutrient stress requires IP3R/Ca2+ signalling in glutamatergic interneurons

    Siddharth Jayakumar, Shlesha Richhariya ... Gaiti Hasan
    The transformation of fruit fly larvae into pupae provides insights into the processes that enable animals to survive periods of food shortage.
    1. Cancer Biology
    2. Medicine

    Open-top Bessel beam two-photon light sheet microscopy for three-dimensional pathology

    Won Yeong Park, Jieun Yun ... Ki Hean Kim
    Open-top Bessel beam two-photon light sheet microscopy have the potential for rapid and accurate nondestructive pathology by visualizing 3D histological information.
    1. Cell Biology
    2. Developmental Biology

    Cancer: Evolution, ovulation and cancer

    K VijayRaghavan, Satyajit Rath
    Version of Record
    Insight
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structural basis of malodour precursor transport in the human axilla

    Gurdeep S Minhas, Daniel Bawdon ... Simon Newstead
    Discovery of the structural basis for recognition and uptake of a human precursor for body odour production reveals an important role for bacterial peptide transport and novel routes to prevent its production in humans.
    1. Cell Biology

    Unfolded protein response transducer IRE1-mediated signaling independent of XBP1 mRNA splicing is not required for growth and development of medaka fish

    Tokiro Ishikawa, Makoto Kashima ... Kazutoshi Mori
    The unfolded protein response sensor/transducer IRE1-mediated splicing of XBP1 mRNA encoding its active downstream transcription factor to maintain the homeostasis of the endoplasmic reticulum is sufficient for growth and development of medaka fish.
    1. Stem Cells and Regenerative Medicine

    In vivo reprogramming of pancreatic acinar cells to three islet endocrine subtypes

    Weida Li, Mio Nakanishi ... Qiao Zhou
    Combinations of transcription factors can convert pancreatic acinar cells into endocrine α-, β- and δ-cells in vivo.
    1. Medicine
    2. Immunology and Inflammation

    Identification of novel, clinically correlated autoantigens in the monogenic autoimmune syndrome APS1 by proteome-wide PhIP-Seq

    Sara E Vazquez, Elise MN Ferré ... Mark S Anderson
    Humans with mutations in the AIRE gene exhibit common autoantibodies targeting ovarian and intestinal antigens, including intestinal dysfunction-associated antibodies to enteroendocrine transcription factor RFX6.
    1. Neuroscience

    Identification of the trail-following pheromone receptor in termites

    Souleymane Diallo, Kateřina Kašparová ... Robert Hanus
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling