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    1. Cell Biology
    2. Neuroscience

    Large vesicle extrusions from C. elegans neurons are consumed and stimulated by glial-like phagocytosis activity of the neighboring cell

    Yu Wang, Meghan Lee Arnold ... Barth D Grant
    Giant neuron derived vesicles called exophers are processed by phagocytosis in neighboring skin cells, and the phagocytic interaction promotes exopher production.
    1. Cell Biology

    Kazrin promotes dynein/dynactin-dependent traffic from early to recycling endosomes

    Ines Hernandez-Perez, Javier Rubio ... María Isabel Geli
    Kazrin, a protein widely expressed in vertebrates whose depletion causes defects in cell adhesion and migration, is recruited to early endosomes and promotes dynein/dynactin-dependent traffic of endocytosed cargo to the recycling endosomes.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Protein flexibility is required for vesicle tethering at the Golgi

    Pak-yan Patricia Cheung, Charles Limouse ... Suzanne R Pfeffer
    Atomic force microscopy reveals a floppy, dimeric, coiled coil Golgin structure that captures transport vesicles via splayed, N-terminal ends at the Golgi complex.
    1. Cell Biology

    Mucosal absorption of therapeutic peptides by harnessing the endogenous sorting of glycosphingolipids

    Maria Daniela Garcia-Castillo, Daniel J-F Chinnapen ... Wayne I Lencer
    Non-native synthetic short-chain glycosphingolipids fused to GLP-1 enable intestinal absorption with high bioavailability in vivo.
    1. Plant Biology

    RPG acts as a central determinant for infectosome formation and cellular polarization during intracellular rhizobial infections

    Beatrice Lace, Chao Su ... Thomas Ott
    Infectosomes enabling polar progression of infection threads in legume roots require the symbioisis-related RPG protein that functions as an organizer of these structures.
    1. Developmental Biology

    Cytoplasmic sharing through apical membrane remodeling

    Nora G Peterson, Benjamin M Stormo ... Donald T Fox
    Apical membrane remodeling in a resorptive Drosophila epithelium generates a shared multinuclear cytoplasm.
    1. Plant Biology

    CASP microdomain formation requires cross cell wall stabilization of domains and non-cell autonomous action of LOTR1

    Andreas Kolbeck, Peter Marhavý ... Niko Geldner
    Localized lignin impregnations, forming a pan-endodermal net-like diffusion barrier strongly relies on stabilizing signals from neighbors.
    1. Neuroscience

    A conserved morphogenetic mechanism for epidermal ensheathment of nociceptive sensory neurites

    Nan Jiang, Jeffrey P Rasmussen ... Jay Z Parrish
    Epidermal cells in vertebrates and invertebrates ensheath portions of somatosensory neurons via a conserved morphogenetic mechanism, and this ensheathment regulates morphogenesis and function of Drosophila nociceptive neurons.
    1. Cell Biology
    2. Immunology and Inflammation

    Microtubules restrict F-actin polymerization to the immune synapse via GEF-H1 to maintain polarity in lymphocytes

    Judith Pineau, Léa Pinon ... Paolo Pierobon
    Microfluidics and dynamic imaging allow systematic characterization of polarization kinetics in B lymphocytes and highlight the role of microtubules as master regulators of actin polymerization at the immune synapse.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A conserved and regulated mechanism drives endosomal Rab transition

    Lars Langemeyer, Ann-Christin Borchers ... Christian Ungermann
    Reconstitution of the endosomal Rab cascade reveals that Rab5 binds and activates the Mon1-Ccz1 guanine nucleotide exchange factor, which in turn recruits Rab7 to membranes to drive fusion.