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    1. Cell Biology

    EGF receptor signaling, phosphorylation, ubiquitylation and endocytosis in tumors in vivo

    Itziar Pinilla-Macua et al.
    A small pool of active epidermal growth factor (EGF) receptors, which are capable of ubiquitylation and efficient endocytosis in vivo, is sufficient to support EGF-receptor-dependent tumor growth by signaling primarily through the Ras-MAPK pathway.
    1. Cell Biology
    2. Neuroscience

    A synaptic F-actin network controls otoferlin-dependent exocytosis in auditory inner hair cells

    Philippe FY Vincent et al.
    A synaptic F-actin network tightly controls the flow of synaptic vesicles during exocytosis at the inner hair cell ribbons.
    1. Cell Biology

    The AP-2 complex has a specialized clathrin-independent role in apical endocytosis and polar growth in fungi

    Olga Martzoukou et al.
    In filamentous fungi the AP-2 complex, which in mammals is an adaptor of clathrin-mediated endocytosis, is recruited to specific clathrin-independent apical endocytosis necessary for proper lipid maintenance and polar growth.
    1. Cell Biology

    Direct comparison of clathrin-mediated endocytosis in budding and fission yeast reveals conserved and evolvable features

    Yidi Sun et al.
    Quantitative comparison of clathrin-mediated endocytosis in budding and fission yeast identified conserved mechanisms and species-specific adaptations with broad implications that extend from yeast to humans.
    1. Cell Biology

    Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis

    Alenka Guček et al.
    Live cell imaging shows that the cAMP-sensor Epac2, a target of major antidiabetic drugs, is central to fusion pore control during insulin granule exocytosis.
    1. Neuroscience

    A mechanism for exocytotic arrest by the Complexin C-terminus

    Mazen Makke et al.
    The far C-terminal domain of CpxII interferes with SNARE assembly and thereby arrests tonic exocytosis.
    1. Cell Biology
    2. Neuroscience

    Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis

    Alexander M Walter et al.
    Increasing PI(4,5)P2 on a sub-second timescale using a novel, membrane-permeant UV activatable PI(4,5)P2 molecule augments exocytosis which requires the PI(4,5)P2 interacting exocytotic proteins Munc13-2 and synaptotagmin-1.
    1. Developmental Biology

    Requirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception

    Shen Yue et al.
    Smurf1 and Smurf2 have essential functions in the mammalian Shh signaling pathway, binding to and ubiquitylating Patched1, leading to its endocytosis and subsequent degradation in lysosomes.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Massive endocytosis triggered by surface membrane palmitoylation under mitochondrial control in BHK fibroblasts

    Donald W Hilgemann et al.
    Mitochondria can trigger massive endocytosis by releasing coenzyme A into the cytoplasm and thereby promoting the addition of fatty acids to surface membrane proteins.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Massive palmitoylation-dependent endocytosis during reoxygenation of anoxic cardiac muscle

    Mei-Jung Lin et al.
    Reoxygenation of anoxic cardiac tissue promotes massive endocytosis that is triggered by release of coenzymeA from mitochondria, followed by palmitoylation of membrane proteins, sarcolemma vesiculation, and transfer of sarolemma vesicles to large endosomes and vacuoles.