2,259 results found
    1. Cell Biology
    2. Developmental Biology

    The exon junction complex regulates the splicing of cell polarity gene dlg1 to control Wingless signaling in development

    Min Liu et al.
    The exon junction complex regulates the cell polarity determinant Discs large 1, which acts independently from its role in cell polarity to protect Dishevelled protein from lysosomal degradation in Wingless/Wnt signaling.
    1. Chromosomes and Gene Expression

    Exon junction complex proteins bind nascent transcripts independently of pre-mRNA splicing in Drosophila melanogaster

    Subhendu Roy Choudhury et al.
    Deposition of the exon junction complex is thought to be the missing link between pre-mRNA splicing and translation in multicellular organisms, but no evidence of such deposition has been found in Drosophila.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    ICE1 promotes the link between splicing and nonsense-mediated mRNA decay

    Thomas D Baird et al.
    A whole-genome siRNA screen identifies ICE1 as a factor required for accurate sensing and quality control of mRNAs containing premature stop codons.
    1. Neuroscience

    Visual Behavior: The eyes have it

    Mehmet Keleş, Mark A Frye
    Molecular genetic experiments are revealing how the fly brain generates behavioral responses to visual stimuli.
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    1. Neuroscience

    Axons: The cost of communication in the brain

    Brian A MacVicar et al.
    Imaging ATP in axons reveals that they rely on glucose from the blood and lactate produced by glial cells as sources of energy.
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    1. Microbiology and Infectious Disease

    Evolution: ANP32B, or not to be, that is the question for influenza virus

    Steven F Baker, Andrew Mehle
    The evolutionary history of ANP32 proteins impacts how the influenza virus jumps from birds to mammals.
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    1. Neuroscience

    Neuromuscular Disease: Protecting the nerve terminals

    Jonathan D Glass
    Maintaining the connections between nerve cells and muscle could help to slow the progression of amyotrophic lateral sclerosis.
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    1. Neuroscience

    Regeneration: Regrowing axons with alternative splicing

    Nicholas J Kramer, Aaron D Gitler
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