Conditional deletion of the DYT1 dystonia protein torsinA causes selective cell autonomous neurodegeneration of striatal and brainstem cholinergic neurons, and severe motor behavioral abnormalities.
CaMKII and the actin-crosslinking protein α-actinin-2 associate within minutes of the induction of long-term potentiation and disrupting this interaction prevents formation of enlarged dendritic spines.
Uncovering an link between plant defense signaling and vertebrate feeding behavior suggests that large browsers may exert strong selection pressure on jasmonate-dependent secondary metabolites.
Jefferson J Doyle, Alexander J Doyle ... MIBAVA Leducq Consortium
Calcium channel blockers accelerate aortic aneurysm and cause premature aortic rupture in a mouse model of Marfan syndrome through protein kinase C-mediated activation of extracellular signal-regulated kinase.
Monika E Dolega, Sylvain Monnier ... Giovanni Cappello
Theoretical predictions and experiments on multicellular aggregates indicate that the extracellular matrix acts as a mechanical sensor, which regulates cell proliferation and migration in a three-dimensional environment.
