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    1. Evolutionary Biology
    2. Genetics and Genomics

    Rapid sex-specific adaptation to high temperature in Drosophila

    Sheng-Kai Hsu et al.
    Within 100 generations after an environmental shift in an evolution experiment, rapid sex-specific adaptation occurred, which is potentially facilitated by selection on standing variation in sex-specific genetic architecture.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The evolutionary plasticity of chromosome metabolism allows adaptation to constitutive DNA replication stress

    Marco Fumasoni, Andrew W Murray
    Evolutionary adaptation to a constitutive perturbation of DNA replication reveals that adaptive mutations in three conserved pathways interact to restore faithful chromosome replication and segregation.
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    Complex chromosomal neighborhood effects determine the adaptive potential of a gene under selection

    Magdalena Steinrueck, Călin C Guet
    Experimental evolution reveals how adaptation by increased expression of a gene depends on a combination of simple genetic properties of the gene's neighbors on the DNA.
    1. Evolutionary Biology

    Long read sequencing reveals poxvirus evolution through rapid homogenization of gene arrays

    Thomas A Sasani et al.
    An adaptive process of genetic homogenization in poxviruses facilitates the propagation of single nucleotide variation within gene copies and might favor the persistence of large gene copy arrays.
    1. Genetics and Genomics

    An incoherent feedforward loop facilitates adaptive tuning of gene expression

    Jungeui Hong et al.
    The architecture of a gene regulatory network determines the effect of evolutionary changes in transcription factor binding.
    1. Cell Biology
    2. Genetics and Genomics

    A mitochondrial DNA hypomorph of cytochrome oxidase specifically impairs male fertility in Drosophila melanogaster

    Maulik R Patel et al.
    A 'male-harming' mtDNA mutation has been identified in Drosophila and impairs male fertility without impairing other male or female functions.
    1. Cell Biology
    2. Evolutionary Biology

    Evolutionary adaptation after crippling cell polarization follows reproducible trajectories

    Liedewij Laan et al.
    Deletion of one gene can lead to inactivation of other genes which restore a perturbed cellular function but change the epistatic interactions and the dynamics of the responsible module.
    1. Evolutionary Biology

    Phenotypic and molecular evolution across 10,000 generations in laboratory budding yeast populations

    Milo S Johnson et al.
    Experimentally evolved yeast populations increase in fitness predictably but do not divide into coexisting lineages or dramatically increase their mutation rates after 10,000 generations.
    1. Evolutionary Biology

    RNA chaperones buffer deleterious mutations in E. coli

    Marina Rudan et al.
    The overexpression of RNA chaperones, including several DEAD box RNA helicases, enhances the fitness of mutationally compromised E. coli strains.
    1. Genetics and Genomics

    Multi-species, multi-transcription factor binding highlights conserved control of tissue-specific biological pathways

    Benoit Ballester et al.
    Combinatorial transcription factor binding shared by multiple species enriches for essential biological pathways and coincides with disease-causing regulatory DNA mutations.