6,423 results found
    1. Neuroscience

    MTL neurons phase-lock to human hippocampal theta

    Daniel R Schonhaut, Aditya M Rao ... Michael J Kahana
    Neural spiking throughout the MTL is synchronous with hippocampal theta phase during spatial memory and navigation experiments in humans, even after controlling for phase-coupling to local theta oscillations.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Antigenic drift and subtype interference shape A(H3N2) epidemic dynamics in the United States

    Amanda C Perofsky, John Huddleston ... Cécile Viboud
    Antigenic drift in influenza’s major surface proteins, hemagglutinin and neuraminidase, contributes to variability in epidemic magnitude across seasons but is less influential than subtype interference in shaping annual outbreaks.
    1. Developmental Biology

    Basement membranes are crucial for proper olfactory placode shape, position and boundary with the brain, and for olfactory axon development

    Pénélope Tignard, Karen Pottin ... Marie Anne Breau
    Laminin gamma1-dependent basement membranes are required for multiple aspects of olfactory system development in zebrafish, including the maintenance of placode tissue shape and the growth of the olfactory axons.
    1. Cancer Biology
    2. Computational and Systems Biology

    Comprehensive machine-learning survival framework develops a consensus model in large-scale multicenter cohorts for pancreatic cancer

    Libo Wang, Zaoqu Liu ... Yu-ling Sun
    AIDPS derived by 76 machine-learning algorithm combinations in 13 independent multicenter cohorts exhibited superior capability than clinical traits and 86 published prognostic signatures and could serve as an ideal biomarker for stratified management and individualized treatment of pancreatic cancer.
    1. Neuroscience

    Neural evidence accumulation persists after choice to inform metacognitive judgments

    Peter R Murphy, Ian H Robertson ... Redmond G O'Connell
    Error detection is contingent on the continuation of evidence accumulation after choice commitment, and the speed and accuracy of this process are modulated by high-level signals from medial frontal cortex.
    1. Neuroscience

    ‘Fearful-place’ coding in the amygdala-hippocampal network

    Mi-Seon Kong, Eun Joo Kim ... Jeansok J Kim
    By recording simultaneous spike trains from fear-responsive basal amygdala (BA) and place-responsive dorsal hippocampus (dHPC) neurons in rats foraging for food in a risky predatory situation, a novel BA-dHPC circuit coding mechanism for interfacing danger and place information was revealed.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    GFPT2/GFAT2 and AMDHD2 act in tandem to control the hexosamine pathway

    Virginia Kroef, Sabine Ruegenberg ... Martin Sebastian Denzel
    AMDHD2 restricts the activity of the essential hexosamine pathway in mouse embryonic stem cells where GFPT2/GFAT2 instead of the common paralog GFPT1/GFAT1 controls metabolite entry.
    1. Cell Biology

    Crumbs is an essential regulator of cytoskeletal dynamics and cell-cell adhesion during dorsal closure in Drosophila

    David Flores-Benitez, Elisabeth Knust
    The evolutionarily conserved polarity protein Crumbs links the regulation of cytoskeleton dynamics and cell-cell adhesion with epithelial morphogenesis.
    1. Neuroscience

    Emergence of brain-like mirror-symmetric viewpoint tuning in convolutional neural networks

    Amirhossein Farzmahdi, Wilbert Zarco ... Tal Golan
    Mirror-symmetric view tuning in the macaque AL face patch can be explained by the spatial pooling of learned reflection-equivariant representations.
    1. Developmental Biology

    Dynamic compartmentalization of the pro-invasive transcription factor NHR-67 reveals a role for Groucho in regulating a proliferative-invasive cellular switch in C. elegans

    Taylor N Medwig-Kinney, Brian A Kinney ... David Q Matus
    Dynamic compartmentalization of the pro-invasive transcription factor NHR-67 reveals a role for members of the Groucho/TCF repressive complex in maintaining non-invasive cell fate in C. elegans.

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