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    1. Neuroscience
    2. Physics of Living Systems

    Continuous, long-term crawling behavior characterized by a robotic transport system

    James Yu, Stephanie Dancausse ... Mason Klein
    Drosophila larvae manipulated by an automated system can be observed for 30+ hr, and new analysis methods of long-timescale trajectories reveal behavioral features previously inaccessible, such as a bimodal distribution of thermal navigation efficiency in individual animals.
    1. Neuroscience

    Controllability boosts neural and cognitive signatures of changes-of-mind in uncertain environments

    Marion Rouault, Aurélien Weiss ... Valentin Wyart
    Task controllability manipulations reveal that information seeking is associated with reduced confidence and active hypothesis testing, as well as stronger neurophysiological correlates of attention and arousal.
    1. Neuroscience

    Hippocampal theta coordinates memory processing during visual exploration

    James E Kragel, Stephen VanHaerents ... Donna J Bridge
    Eye movements time-locked to retrieval and novelty during learning preferentially occur at distinct phases of hippocampal theta.
    1. Computational and Systems Biology
    2. Neuroscience

    Tuning movement for sensing in an uncertain world

    Chen Chen, Todd D Murphey, Malcolm A MacIver
    Animals work in a world full of surprises, where using energy to position sensors proportional to the location's expected information avoids the pitfalls of positioning them at the information maxima.
    1. Neuroscience

    Pallidal neuromodulation of the explore/exploit trade-off in decision-making

    Ana Luisa de A Marcelino, Owen Gray ... Tom Gilbertson
    Deep brain stimulation (DBS) exhibit that the excitability of the basal ganglia can govern the trade off between exploiting available resources or exploring alternative courses of action.
    1. Microbiology and Infectious Disease

    Research: A comprehensive and quantitative exploration of thousands of viral genomes

    Gita Mahmoudabadi, Rob Phillips
    A compendium of critical genomic numbers for viruses through the lenses of different viral classification systems.
    1. Neuroscience

    Accelerating with FlyBrainLab the discovery of the functional logic of the Drosophila brain in the connectomic and synaptomic era

    Aurel A Lazar, Tingkai Liu ... Yiyin Zhou
    FlyBrainLab is an open-source computing platform that integrates 3D exploration and visualization of diverse Drosophila connectomic/synaptomic datasets with interactive exploration of the functional logic of modeled executable brain circuits.
    1. Cancer Biology

    Exploration of drug resistance mechanisms in triple negative breast cancer cells using a microfluidic device and patient tissues

    Wanyoung Lim, Inwoo Hwang ... Sungsu Park
    A microfluidic device induces doxorubicin-resistant polyaneuploid cancer cells from triple negative breast cancer cells, revealing NUPR1/HDAC11 axis dysfunction drives chemoresistance, increasing tumor heterogeneity and impacting clinical outcomes.
    1. Computational and Systems Biology
    2. Neuroscience

    Mice in a labyrinth show rapid learning, sudden insight, and efficient exploration

    Matthew Rosenberg, Tony Zhang ... Markus Meister
    Mice exploring a labyrinth freely for the first time learn a complex action sequence after a handful of rewards, exhibiting a learning rate 1000-fold higher than in commonly-used paradigms.
    1. Computational and Systems Biology
    2. Developmental Biology

    MorphoFeatures for unsupervised exploration of cell types, tissues, and organs in volume electron microscopy

    Valentyna Zinchenko, Johannes Hugger ... Anna Kreshuk
    Unsupervised machine learning on the ultrastructure and shape of cells in volume electron microscopy yields a compact representation of cellular morphology that complements genetics-based cell type characterisation.