3,651 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Distinct RanBP1 nuclear export and cargo dissociation mechanisms between fungi and animals

    Yuling Li et al.
    Animal RanBP1 nuclear export and cargo dissociation mechanisms are surprisingly different from yeast, due to mutations of critical residues, leading to greater nuclear transport efficiency and higher energy cost.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs

    Ian A Roundtree et al.
    YTHDC1 facilitates selective clearance of N6-methyladenosine methylated mRNAs from the nucleus to the cytoplasm through binding by nuclear 'reader' proteins and incorporation into the canonical mRNA export pathway.
    1. Cell Biology

    Nuclear export of misfolded SOD1 mediated by a normally buried NES-like sequence reduces proteotoxicity in the nucleus

    Yongwang Zhong et al.
    Cellular and genetic approaches reveal that exposure of a normally buried nuclear export signal (NES)-like sequence mediates export of ALS-linked mutant and misfolded wild-type SOD1 to the cytoplasm by CRM1.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A non-canonical mechanism for Crm1-export cargo complex assembly

    Ute Fischer et al.
    Slx9 is a newly discovered type of RanGTP-binding protein required for Crm1-mediated nuclear export.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural determinants of nuclear export signal orientation in binding to exportin CRM1

    Ho Yee Joyce Fung et al.
    Some nuclear export signals (NESs) bind to the transport receptor CRM1 in the opposite orientation to those previously studied.
    1. Microbiology and Infectious Disease

    An aspartyl protease defines a novel pathway for export of Toxoplasma proteins into the host cell

    Michael J Coffey et al.
    The Toxoplasma parasite requires an enzyme called ASP5 to cleave proteins for export into host cells.
    1. Cell Biology
    2. Immunology and Inflammation

    IRAK2 directs stimulus-dependent nuclear export of inflammatory mRNAs

    Hao Zhou et al.
    The stimulation of lipopolysaccharides induced nuclear localization of IRAK2 to facilitate nuclear export of a specific subset of inflammation-related messenger RNAs for translation in murine macrophages.
    1. Structural Biology and Molecular Biophysics

    Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals

    Ho Yee Joyce Fung et al.
    Building on previous work (Fung et al., 2015), the structures of eight new nuclear export signal (NES) peptides bound to Exportin CRM1 are reported, revealing striking diversity in NES structures, a small conserved secondary structural element, and a CRM1 residue that functions as a selectivity filter.
    1. Cell Biology

    SLY1 and Syntaxin 18 specify a distinct pathway for procollagen VII export from the endoplasmic reticulum

    Cristina Nogueira et al.
    A cross-linking screen finds proteins that interact with TANGO1 to export Procollagen VII, and suggests a new model for the secretion of these bulky cargoes that are involved in skin and bone formation.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    The export receptor Crm1 forms a dimer to promote nuclear export of HIV RNA

    David S Booth et al.
    The nuclear export receptor Crm1 cooperatively binds its HIV Rev-RRE cargo as a dimer using a species-specific interface that supports viral replication by enhancing nuclear export of HIV RNA.

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