6,216 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator

    Jennifer Jung et al.
    An image-based multiplex autophagosome RNAi screen targeting all Rab GTPases as well as their GAPs and GEFs identifies the Rab GEF SMCR8 as multifaceted autophagy modulator, which regulates kinase activity and gene expression of ULK1.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Adequate immune response ensured by binary IL-2 and graded CD25 expression in a murine transfer model

    Franziska Fuhrmann et al.
    A murine adoptive transfer model shows that binary IL-2 and graded CD25 expression tailor the T helper cell response to the antigen amount in vivo.
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    Avoidance of stochastic RNA interactions can be harnessed to control protein expression levels in bacteria and archaea

    Sinan Uğur Umu et al.
    Stochastic mRNA and non-coding RNA hybridisation has a major impact on protein expression.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Expression site attenuation mechanistically links antigenic variation and development in Trypanosoma brucei

    Christopher Batram et al.
    The VSG gene controls its monoallelic expression, and expression site activity determines developmental progression.
    1. Evolutionary Biology

    Fitness effects of altering gene expression noise in Saccharomyces cerevisiae

    Fabien Duveau et al.
    The impact of changing gene expression noise on fitness reveals beneficial or deleterious effects in a stable environment depending how close the average expression level is to the fitness optimum.
    1. Neuroscience

    Occurrence of long-term depression in the cerebellar flocculus during adaptation of optokinetic response

    Takuma Inoshita, Tomoo Hirano
    Motor training decreased the unit synaptic response and suppressed induction of long-term depression at parallel fiber to Purkinje cell synapses in the cerebellum, supporting involvement of long-term depression in motor learning.
    1. Cancer Biology
    2. Computational and Systems Biology

    Simultaneous enumeration of cancer and immune cell types from bulk tumor gene expression data

    Julien Racle et al.
    A novel method predicts cancer and immune cell types from bulk tumor gene expression data with the ability to consider uncharacterized and possibly highly variable cell types, which is validated in human genome.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Expression noise facilitates the evolution of gene regulation

    Luise Wolf et al.
    In-lab evolution of synthetic promoters has revealed a novel general mechanism for de novo evolution of gene regulation, and highlights the crucial role of expression noise in this process.
    1. Cell Biology

    Experimental reconstitution of chronic ER stress in the liver reveals feedback suppression of BiP mRNA expression

    Javier A Gomez, D Thomas Rutkowski
    Feedback mechanisms that contribute to the deactivation of the unfolded protein response lead to the dysregulation of mRNA expression during chronic stress in the liver, including that of the critical endoplasmic reticulum chaperone BiP.
    1. Chromosomes and Gene Expression

    Chromosome-wide mechanisms to decouple gene expression from gene dose during sex-chromosome evolution

    Bayly S Wheeler et al.
    A chromosome-wide mechanism balances X-linked gene expression between the sexes in C. elegans, but no similar chromosome-wide mechanism balances gene expression between X chromosomes and autosomes.

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