8,278 results found
    1. Evolutionary Biology
    2. Genetics and Genomics

    Cis-regulatory variants affect gene expression dynamics in yeast

    Ching-Hua Shih, Justin Fay
    Allele differences in gene expression dynamics are associated with insertions and deletions and are caused in part by multiple variants within the same promoter region.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Dynamic effects of genetic variation on gene expression revealed following hypoxic stress in cardiomyocytes

    Michelle C Ward, Nicholas E Banovich ... Yoav Gilad
    Cellular stress in a disease-relevant cell type uncovers novel genetic effects on gene expression, which is likely relevant for disease.
    1. Immunology and Inflammation

    Analysis of combinatorial chemokine receptor expression dynamics using multi-receptor reporter mice

    Laura Medina-Ruiz, Robin Bartolini ... Gerard J Graham
    The use of multi-chemokine receptor reporter mice helps to unravel the dynamics of receptor involvement in leukocyte migration in vivo and suggests specificity, rather than redundancy, in receptor use.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Pathway dynamics can delineate the sources of transcriptional noise in gene expression

    Lucy Ham, Marcel Jackson, Michael PH Stumpf
    There are fundamental limits to what can be learned about the origins of transcriptional noise from gene expression data alone, which can be overcome by simultaneously quantifying the abundances of linked molecular species.
    1. Neuroscience

    Shape-invariant encoding of dynamic primate facial expressions in human perception

    Nick Taubert, Michael Stettler ... Martin A Giese
    Contrasting with neural network theories, a study of the cross-species perception of dynamic faces with highly realistic human and monkey avatars reveals independent perceptual encoding of facial shape and expression.
    1. Genetics and Genomics

    Human embryoid bodies as a novel system for genomic studies of functionally diverse cell types

    Katherine Rhodes, Kenneth A Barr ... Yoav Gilad
    Embryoid bodies produce diverse cell types and can enable the study of gene regulatory dynamics at unprecedented spatial and temporal resolution.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Dynamic regulation of chromatin accessibility by pluripotency transcription factors across the cell cycle

    Elias T Friman, Cédric Deluz ... David M Suter
    OCT4 and SOX2 display partially independent activity to regulate chromatin accessibility, and highly dynamic activity of OCT4 is required throughout the cell cycle to maintain pluripotency enhancer accessibility.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Quantitative control of noise in mammalian gene expression by dynamic histone regulation

    Deng Tan, Rui Chen ... Wei Huang
    Ubiquitous transcriptional factor-CBP/p300 interaction induces epigenetic and transcriptional bimodality, which can be utilized to tune mean gene expression and noise independently.
    1. Cell Biology

    Enhanced single RNA imaging reveals dynamic gene expression in live animals

    Yucen Hu, Jingxiu Xu ... Weirui Ma
    The combination of the MS2 system with the Suntag system as a signal amplifier allows enhanced single-molecule mRNA imaging in live cells and animals.
    1. Cell Biology
    2. Computational and Systems Biology

    Limits on information transduction through amplitude and frequency regulation of transcription factor activity

    Anders S Hansen, Erin K O'Shea
    The ability of cells to transmit information encoded in signaling dynamics is fundamentally limited by the gene decoding step.

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