8,870 results found
    1. Plant Biology

    Building customizable auto-luminescent luciferase-based reporters in plants

    Arjun Khakhar et al.
    A fungal bioluminescence pathway can be reconstituted in planta to create luminescence in many plant species without external substrate addition, and be used to design customizable reporters of gene-expression.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Elba, a novel developmentally regulated chromatin boundary factor is a hetero-tripartite DNA binding complex

    Tsutomu Aoki et al.
    A chromatin boundary factor that is only active during early embryo development has been discovered in Drosophila.
    1. Computational and Systems Biology

    Synthetic and genomic regulatory elements reveal aspects of cis-regulatory grammar in mouse embryonic stem cells

    Dana M King et al.
    The independent effects of transcription factor binding sites are large regardless of sequence context, but the interactions between sites are context dependent.
    1. Cancer Biology

    Functional interrogation of HOXA9 regulome in MLLr leukemia via reporter-based CRISPR/Cas9 screen

    Hao Zhang et al.
    The HOXA9 reporter and genetic screens facilitated the functional interrogation of the HOXA9 regulome and advanced our understanding of the molecular regulation network in HOXA9-driven leukemia.
    1. Cancer Biology
    2. Cell Biology

    Club cells form lung adenocarcinomas and maintain the alveoli of adult mice

    Magda Spella et al.
    Airway cells are required for the maintenance of the adult mouse lung and for carcinogen-induced lung adenocarcinoma development, and are thus marked therapeutic targets.
    1. Chromosomes and Gene Expression

    Dimerisation of the PICTS complex via LC8/Cut-up drives co-transcriptional transposon silencing in Drosophila

    Evelyn L Eastwood et al.
    Heterochromatin formation at transposon loci depends on dimerisation of the effector complex that elicits co-transcriptional silencing and this requirement is fulfilled by co-option of the conserved dimerisation hub protein, Cut-up/LC8.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Further support for aneuploidy tolerance in wild yeast and effects of dosage compensation on gene copy-number evolution

    Audrey P Gasch et al.
    Many natural isolates of budding yeast carry extra chromosome copies and show lower-than-expected expression at a subset of amplified genes, which show unique evolutionary signatures.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Global, cell non-autonomous gene regulation drives individual lifespan among isogenic C. elegans

    Holly E Kinser et al.
    Expression of almost half of a library of fluorescent reporters distinguish long- from short-lived individual Caenorhabditis elegans, suggesting that organism-wide differences in gene expression drive future lifespan.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation

    Qin Li et al.
    PTBP2 ensures that adult protein variants are expressed only in mature neurons through regulation of alternative splicing during early neuronal development.

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