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    1. Developmental Biology
    2. Neuroscience

    linc-mipep and linc-wrb encode micropeptides that regulate chromatin accessibility in vertebrate-specific neural cells

    Valerie A Tornini, Liyun Miao ... Antonio J Giraldez
    Two putative long noncoding RNAs in zebrafish encode micropeptides with homology to the vertebrate-specific chromatin architectural protein, Hmgn1, which are required for development of vertebrate-specific brain cell types.
    1. Evolutionary Biology
    2. Genetics and Genomics

    A common 1.6 mb Y-chromosomal inversion predisposes to subsequent deletions and severe spermatogenic failure in humans

    Pille Hallast, Laura Kibena ... Maris Laan
    In addition to its academic merits, characterizing the genetic determinants of male (in)fertility and identifying clinically actionable genetic variants can lead to improved diagnosis or even treatment of such conditions.
    1. Evolutionary Biology
    2. Genetics and Genomics

    A de novo evolved gene in the house mouse regulates female pregnancy cycles

    Chen Xie, Cemalettin Bekpen ... Diethard Tautz
    A female specifically expressed new protein-coding gene that has emerged out of non-coding sequences without detectable signatures of adaptive evolution affects female pregnancy cycles.
    1. Medicine

    Infrared molecular fingerprinting of blood-based liquid biopsies for the detection of cancer

    Marinus Huber, Kosmas V Kepesidis ... Mihaela Zigman
    The combination of molecular infrared fingerprinting and machine learning enables the detection of breast, bladder, prostate, and lung cancer based on liquid blood serum and plasma, providing a general framework for the minimally invasive investigation of oncological conditions.
    1. Plant Biology

    A roadmap for gene functional characterisation in crops with large genomes: Lessons from polyploid wheat

    Nikolai M Adamski, Philippa Borrill ... Cristobal Uauy
    The development of genomic tools and publicly available resources in polyploid wheat provides a framework to understand biologically important traits in crops with large genomes.
    1. Plant Biology

    Glutaredoxin regulation of primary root growth is associated with early drought stress tolerance in pearl millet

    Carla de la Fuente, Alexandre Grondin ... Laurent Laplaze
    Increased primary root growth in pearl millet is correlated with early water stress tolerance, an important constraint in agrosystems in the Sahel, and is associated with the regulation of root cell elongation by a glutaredoxin.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Longitudinal imaging of Caenorhabditis elegans in a microfabricated device reveals variation in behavioral decline during aging

    Matthew A Churgin, Sang-Kyu Jung ... Christopher Fang-Yen
    The WorMotel, a novel microfabricated device for automated longitudinal imaging of aging in large numbers of Caenorhabditis elegans, reveals that long and short lived strains vary in their behavioral decline during aging in a similar way to the long and short lived individuals in a wild type population.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Host-pathogen genetic interactions underlie tuberculosis susceptibility in genetically diverse mice

    Clare M Smith, Richard E Baker ... Christopher M Sassetti
    A novel dual genome approach that combines genetically diverse mice and a library of bacterial mutants to define the genome-wide host pathogen interactions that drive distinct outcomes to tuberculosis.
    1. Evolutionary Biology

    Compensatory evolution drives multidrug-resistant tuberculosis in Central Asia

    Matthias Merker, Maxime Barbier ... Stefan Niemann
    The genetic make-up of dominating MDR-TB clades in Central Asia is shaped by programmatic and socio-economic changes that led to fixation of resistance and bacterial fitness related mutations in the Soviet era.
    1. Cell Biology

    Mapping variation in the morphological landscape of human cells with optical pooled CRISPRi screening

    Ramon Lorenzo D. Labitigan, Adrian L. Sanborn ... Julie A. Theriot
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling