691 results found
    1. Cell Biology
    2. Developmental Biology

    PI3K/Akt1 signalling specifies foregut precursors by generating regionalized extra-cellular matrix

    S Nahuel Villegas et al.
    A signalling cascade involving PI3K/Akt1 remodels the extra-cellular matrix to achieve atypical cellular responses and control cell fate specification within the embryonic endoderm.
    1. Structural Biology and Molecular Biophysics

    Structure-based membrane dome mechanism for Piezo mechanosensitivity

    Yusong R Guo, Roderick MacKinnon
    Mechanosensitive Piezo channel induces local membrane curvature to mediate mechanical gating.
    1. Cell Biology
    2. Developmental Biology

    FBN-1, a fibrillin-related protein, is required for resistance of the epidermis to mechanical deformation during C. elegans embryogenesis

    Melissa Kelley et al.
    A fibrillin-related protein, FBN-1, is a key component of the apical extracellular matrix and prevents epidermal cell deformation by biomechanical forces during morphogenesis of the C. elegans embryo.
    1. Neuroscience

    Noninvasive quantification of axon radii using diffusion MRI

    Jelle Veraart et al.
    Cell-specific architectural properties such as the axon diameter of the white matter of the human brain can be quantified accurately and non-invasively using diffusion magnetic resonance imaging.
    1. Computational and Systems Biology
    2. Developmental Biology

    Elastic force restricts growth of the murine utricle

    Ksenia Gnedeva et al.
    Computational modeling and molecular-biological analysis reveal the role of mechanical force and downstream Yap signaling in growth control during the development and regeneration of sensory epithelium of the inner ear.
    1. Cell Biology

    Genome-wide interrogation of extracellular vesicle biology using barcoded miRNAs

    Albert Lu et al.
    A screen using artificially barcoded, exosomal microRNAs, paired with CRISPR guide RNAs, helped identify new players in multivesicular endosome exocytosis and a role for Wnt signaling.
    1. Developmental Biology

    Distinct mesoderm migration phenotypes in extra-embryonic and embryonic regions of the early mouse embryo

    Bechara Saykali et al.
    At gastrulation, mesoderm arises as a migratory germ layer that will participate to both foetal and placental development through region-dependant adaptation of cytoskeleton composition, cell shape and migration mode.
    1. Neuroscience

    A muscle-epidermis-glia signaling axis sustains synaptic specificity during allometric growth in Caenorhabditis elegans

    Jiale Fan et al.
    The work uncovers a muscle-epidermis-glia signaling axis, modulated by protease mig-17 and the basement membrane, that regulates synaptic allometry during growth in Caenorhabditis elegans.
    1. Cancer Biology
    2. Stem Cells and Regenerative Medicine

    A single-cell atlas of the mouse and human prostate reveals heterogeneity and conservation of epithelial progenitors

    Laura Crowley et al.
    Single-cell analyses identify distinct epithelial populations that are conserved between the adult mouse and human prostate, including populations with properties of multipotent progenitors in organoid formation and tissue reconstitution assays.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    A cytoplasmic peptidoglycan amidase homologue controls mycobacterial cell wall synthesis

    Cara C Boutte et al.
    Cell wall biosynthesis in mycobacteria is regulated by an unusual post-translational regulatory system that contributes to antibiotic tolerance during stress.

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