544 results found
    1. Developmental Biology

    The vascular niche controls Drosophila hematopoiesis via fibroblast growth factor signaling

    Manon Destalminil-Letourneau et al.
    Two niches contribute to the control of Drosophila blood cell homeostasis through their differential regulation of hematopoietic progenitors.
    1. Ecology
    2. Genetics and Genomics

    Novel adverse outcome pathways revealed by chemical genetics in a developing marine fish

    Elin Sørhus et al.
    Global gene expression analysis unravels the underlying mechanisms for distinct crude oil induced defects in Atlantic haddock eggs and larvae.
    1. Structural Biology and Molecular Biophysics
    2. Biochemistry and Chemical Biology

    Structural mechanism of ligand activation in human calcium-sensing receptor

    Yong Geng et al.
    L-amino acids are agonists of calcium-sensing receptor, and act jointly with calcium and phosphate ions to control receptor function.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structures and functional properties of CALHM channels of the human placenta

    Katarzyna Drożdżyk et al.
    Members of the calcium homeostasis modulator family expressed in the placenta form large channels with unknown activation properties that harbor a lipid bilayer on the inside of a cylindrical pore.
    1. Neuroscience

    A positive feedback loop linking enhanced mGluR function and basal calcium in spinocerebellar ataxia type 2

    Pratap Meera et al.
    A damaging form of positive feedback linking elevated calcium levels and metabotropic glutamate receptor function in Purkinje neurons plays a critical role in the pathology in spinocerebellar ataxias.
    1. Cell Biology

    Intracellular sphingosine releases calcium from lysosomes

    Doris Höglinger et al.
    Sphingosine acts as a lipid messenger molecule in intracellular signaling networks that are relevant to lysosomal function and Niemann-Pick disease.
    1. Developmental Biology

    Calcium handling precedes cardiac differentiation to initiate the first heartbeat

    Richard CV Tyser et al.
    High-resolution live imaging reveals how and when the mouse heart first starts to beat during development and how the onset of beating impacts on heart muscle cell maturation and heart formation.
    1. Neuroscience

    Maintenance of homeostatic plasticity at the Drosophila neuromuscular synapse requires continuous IP3-directed signaling

    Thomas D James et al.
    Synapses employ distinct acute and chronic signaling processes in order to maintain physiologically appropriate levels of function.
    1. Cell Biology
    2. Developmental Biology

    Caenorhabditis elegans PIEZO channel coordinates multiple reproductive tissues to govern ovulation

    Xiaofei Bai et al.
    Depletion of the mechanosensitive ion channel PEZO-1 in C. elegans disrupts the sheath and spermathecae cells to disrupt oocyte ovulation, resulting in crushed oocytes.
    1. Neuroscience

    Spontaneous neurotransmission signals through store-driven Ca2+ transients to maintain synaptic homeostasis

    Austin L Reese, Ege T Kavalali
    Individual neurons can adjust the strength of their synapses by using spontaneous calcium influx through NMDA receptors to trigger the release of additional calcium from intracellular stores, which can in turn be used to regulate protein synthesis.

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