Wnt3 accomplishes long-range distribution by extracellular diffusion controlled by expression, tissue morphology, interactions with heparan sulfate proteoglycans, and co-receptor-mediated receptor binding to regulate brain development in zebrafish embryos.

The collective dynamics of cell signaling relays are at once dramatically sensitive to the system dimensionality and insensitive to many biological details.

Solute movement in brain extracellular space is determined by solute diffusion, and does not depend on convection or aquaporin-4 expression as predicted by the glymphatic mechanism.

Free, extracellular dispersal of Wnt proteins generates a long-range gradient during animal development and is required for signaling.

Wnt distribution is regulated by a dynamic exchange of its abundant scaffold-bound and rare freely diffusing populations, providing insights into a conceived dilemma of speed and stability of tissue patterning.

Channel activity is a novel regulatory mechanism for channel mobility in the plasma membrane.

Patterning of the dorsal-ventral axis in zebrafish is mediated by a graded source-sink mechanism in which diffusing BMP, produced from a ventrally biased source, is inhibited by dorsally-produced chordin.

The slope of the chemoattractant concentration gradient is a driving force for sperm chemotaxis, by coordinating the entrainment of information flow between sensing, signaling and motility.

A combined experimental and computational approach was developed to understand lateral interactions between membrane-bound proteins and used to quantify the contributions of specific and non-specific interactions to cadherin cis-binding kinetics.

The diffusional barrier formed between phagocyte integrin and fungal glucans preserves the microbiostatic phagocytic environment generated during the frustrated phagocytosis of Candida albicans hypha.