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    1. Cell Biology
    2. Cancer Biology

    Plectin-mediated cytoskeletal crosstalk as a target for inhibition of hepatocellular carcinoma growth and metastasis

    Zuzana Outla, Gizem Oyman-Eyrilmez ... Martin Gregor
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A Fyn biosensor reveals pulsatile, spatially localized kinase activity and signaling crosstalk in live mammalian cells

    Ananya Mukherjee, Randhir Singh ... Akash Gulyani
    Unique biosensor design and protein-engineering enables direct visualization of the active form of Fyn kinase with high specificity, minimal perturbation and shows cellular signaling to be compartmentalized and pulsatile.
    1. Cell Biology
    2. Developmental Biology

    Limited column formation in the embryonic growth plate implies divergent growth mechanisms during pre- and postnatal bone development

    Sarah Rubin, Ankit Agrawal ... Elazar Zelzer
    Modulation of division plane rotation in proliferating chondrocytes determines the ratio of clusters and columns, which may support the multifunctional design of the growth plate.
    1. Computational and Systems Biology

    Ear pinnae in a neotropical katydid (Orthoptera: Tettigoniidae) function as ultrasound guides for bat detection

    Christian A Pulver, Emine Celiker ... Fernando Montealegre-Z
    Located in the legs, the miniaturized katydid ears exhibit cuticular pinnae to only capture high-ultrasonic bat echolocation calls, but katydid also hear their own calls using alternative ear paths, which suggest that their ears operate in a colossal frequency range.
    1. Cell Biology
    2. Genetics and Genomics

    T-REX17 is a transiently expressed non-coding RNA essential for human endoderm formation

    Alexandro Landshammer, Adriano Bolondi ... Alexander Meissner
    Discovery of a novel long non-coding RNA overlapping the distal SOX17 enhancer (eSOX17) that plays an essential role in human endoderm development.
    1. Neuroscience

    Salivary and plasmatic oxytocin are not reliable trait markers of the physiology of the oxytocin system in humans

    Daniel Martins, Anthony S Gabay ... Yannis Paloyelis
    Single measurements of baseline salivary and plasmatic oxytocin are not sufficiently reliable to provide valid trait markers of the physiology of the oxytocin system in humans.
    1. Cell Biology

    Single cell transcriptomics identifies a unique adipose lineage cell population that regulates bone marrow environment

    Leilei Zhong, Lutian Yao ... Ling Qin
    A newly identified adipose lineage cell population, MALP, regulates marrow vasculature and osteogenesis in bone.
    1. Neuroscience

    Drosophila Fezf coordinates laminar-specific connectivity through cell-intrinsic and cell-extrinsic mechanisms

    Jing Peng, Ivan J Santiago ... Matthew Y Pecot
    Transcriptional modules underlie the step-wise construction of neural circuits in the Drosophila visual system.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Distinct functional determinants of influenza hemagglutinin-mediated membrane fusion

    Tijana Ivanovic, Stephen C Harrison
    The mechanism of membrane-fusion catalysis in influenza viral infection of target cells is robust against the presence of a large fraction of non-productive viral fusion proteins.
    1. Neuroscience

    TRPV4 overactivation enhances cellular contractility and drives ocular hypertension in TGFβ2 overexpressing eyes

    Christopher N Rudzitis, Monika Lakk ... David Križaj
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Convincing