1,968 results found
    1. Neuroscience

    Apical length governs computational diversity of layer 5 pyramidal neurons

    Alessandro R Galloni et al.
    Layer 5 pyramidal neurons vary substantially in dendritic excitability between primary and secondary visual cortex, likely due to a counterintuitive amplifying effect of long apical dendrites.
    1. Neuroscience

    Global sleep homeostasis reflects temporally and spatially integrated local cortical neuronal activity

    Christopher W Thomas et al.
    The global sleep homeostatic process tracks sleep-wake history by integrating local cortical neuronal activity over time and space, rather than directly reflecting changes in specific homeostatically regulated physiological variables.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Membrane characteristics tune activities of endosomal and autophagic human VPS34 complexes

    Yohei Ohashi et al.
    The lipid kinase VPS34 complexes I and II are both activated by unsaturation of substrate and non-substrate lipids, curvature, electrostatics and polyphosphoinositides, which play roles in localisation and cellular function.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Tgfβ signaling is required for tenocyte recruitment and functional neonatal tendon regeneration

    Deepak A Kaji et al.
    TGFß signaling regulates migration of tenogenic cells from Scx- and non-Scx lineages and is required for functional regeneration after neonatal tendon injury.
    1. Neuroscience

    Inhibition stabilization is a widespread property of cortical networks

    Alessandro Sanzeni et al.
    The strongly coupled theoretical regime describes the function of mouse sensory and motor cortical areas.
    1. Neuroscience

    mPFC spindle cycles organize sparse thalamic activation and recently active CA1 cells during non-REM sleep

    Carmen Varela, Matthew A Wilson
    Sleep spindles provide a temporal framework to organize the reactivation of behaviorally relevant CA1 cells and sparsely active cells in the limbic thalamus.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Slightly beneficial genes are retained by bacteria evolving DNA uptake despite selfish elements

    Bram van Dijk et al.
    Horizontal gene transfer (HGT) helps slightly beneficial genes persist in microbial populations, incentivising cells to invest in costly DNA uptake, even in the presence of harmful selfish genetic elements.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Self-restoration of cardiac excitation rhythm by anti-arrhythmic ion channel gating

    Rupamanjari Majumder et al.
    Customization of ion channel gating enhances homeostatic regulation through automatic detection and correction of abnormal physiological changes, as illustrated by self-restoration of excitation rhythm in cardiac arrhythmias.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Topologically correct synthetic reconstruction of pathogen social behavior found during Yersinia growth in deep tissue sites

    Stacie A Clark et al.
    Tissue infection by an extracellular pathogen is recapitulated by encasing a bacterial colony within a droplet gel to allow immune cell attack, driving spatially-controlled microbial social behavior.
    1. Immunology and Inflammation

    Squalene emulsion-based vaccine adjuvants stimulate CD8 T cell, but not antibody responses, through a RIPK3-dependent pathway

    Eui Ho Kim et al.
    Experiments in mice provide insights into the immunological mechanisms of action the vaccine adjuvant MF59.

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