1,347 results found
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    An elusive electron shuttle from a facultative anaerobe

    Emily Mevers, Lin Su ... Jon Clardy
    The identification of ACNQ as an extracellular electron shuttle solves a longstanding problem in bacterial physiology and provides new tool for bioenergy development.
    1. Neuroscience

    Audiovisual task switching rapidly modulates sound encoding in mouse auditory cortex

    Ryan J Morrill, James Bigelow ... Andrea R Hasenstaub
    The brain processes the same multisensory stimulus differently when the way it sounds, as opposed to the way it looks, is useful for making a decision.
    1. Cell Biology
    2. Neuroscience

    Tenectin recruits integrin to stabilize bouton architecture and regulate vesicle release at the Drosophila neuromuscular junction

    Qi Wang, Tae Hee Han ... Mihaela Serpe
    Characterization of Tnc as a selective integrin ligand at the Drosophila NMJ allows for unprecedented insights into our understanding of extracellular matrix/integrin interactions at synaptic locations and reveals novel, distinct presynaptic and postsynaptic integrin functions.
    1. Cell Biology

    LRG1 is an adipokine that promotes insulin sensitivity and suppresses inflammation

    Chan Hee J Choi, William Barr ... Paul Cohen
    Profiling the adipocyte secretome reveals LRG1 as a novel adipokine that promotes insulin sensitivity and modulates inflammation triggered by release of cytochrome c from dead/dying cells, describing a new pathway at the intersection of obesity and its systemic sequelae.
    1. Biochemistry and Chemical Biology

    Post-translational flavinylation is associated with diverse extracytosolic redox functionalities throughout bacterial life

    Raphaël Méheust, Shuo Huang ... Samuel H Light
    Bioinformatic and biochemical studies provide evidence that covalently bound flavins are common and participate in wide-ranging extracytosolic redox activities throughout bacterial life.
    1. Neuroscience

    Reconciling functional differences in populations of neurons recorded with two-photon imaging and electrophysiology

    Joshua H Siegle, Peter Ledochowitsch ... Saskia EJ de Vries
    Discrepancies between functional responses measured with electrophysiology and calcium imaging can be largely reconciled by considering the spike-to-calcium transfer function, neuronal sampling bias, and cluster merging artifacts during spike sorting.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Extracellular electron transfer increases fermentation in lactic acid bacteria via a hybrid metabolism

    Sara Tejedor-Sanz, Eric T Stevens ... Maria L Marco
    Lactic acid bacteria engage a hybrid metabolism which blends features of fermentation and respiration when they perform extracellular electron transfer.
    1. Computational and Systems Biology

    Control and regulation of acetate overflow in Escherichia coli

    Pierre Millard, Brice Enjalbert ... Fabien Létisse
    Elucidating the control and regulation of acetate overflow in E. coli reveals that acetate is not only an end-product but also a co-substrate and a global regulator of glucose metabolism.
    1. Neuroscience

    Medial entorhinal cortex activates in a traveling wave in the rat

    J Jesús Hernández-Pérez, Keiland W Cooper, Ehren L Newman
    The existence of traveling waves in the medial entorhinal cortex, like those observed in the hippocampus, supports the hypothesis that traveling waves coordinate the activity of anatomically distributed circuits.
    1. Developmental Biology

    Murine blastocysts generated by in vitro fertilization show increased Warburg metabolism and altered lactate production

    Seok Hee Lee, Xiaowei Liu ... Paolo F Rinaudo
    In vitro fertilization-conceived murine embryos show evidence of oxidative and metabolic stress with alteration in lactic acid metabolism.

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