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A new mechanism of receptor desensitization is revealed for the novel proton-activated chloride channel, which plays an important role in physiology and disease associated with acidic pH.

A modified form of Green Fluorescent Protein integrated into an ammonium transporter provides a sensor that can be used to monitor transport activity in vivo.

Enzymatic division of labor is identified as an enabling biochemical strategy for regulating a family of structurally diverse bioactive lipids.

The N-terminus of the FGF14b isoform promotes the inactivation of voltage-gated Na⁺ channels to regulate the resurgent Na⁺ channel current needed for high frequency action potentials.

In red blood cells, the Piezo1 protein is responsible for sensing mechanical forces and volume regulation.

Time-lapse imaging and the modular recreation of host physiology reveal that alveolar epithelial cells, potential permissive infection sites for Mycobacterium tuberculosis, can restrict early bacterial growth via surfactant secretion.

Purinergic signaling controls mammalian sperm transport.

The anti-tuberculosis drug bedaquiline reprograms human macrophages into potent bactericidal phagocytes, which are able to control bacterial infection.

Polyunsaturated fatty acids facilitate or impede Kv7 channel activation, depending on channel subtype and their dominant functional site(s).

The structure of a pannexin 1 uncovers the extracellular loops of pannexin 1 as important structural motifs for ion selectivity and channel inhibition.