1,393 results found
    1. Cell Biology

    A WDR35-dependent coat protein complex transports ciliary membrane cargo vesicles to cilia

    Tooba Quidwai, Jiaolong Wang ... Pleasantine Mill
    Electron tomography and biochemical approaches demonstrate a direct role for WDR35, beyond integrity of the IFT-A holocomplex, in the formation and fusion of electron-dense-coated vesicles to the ciliary sheath and pocket for delivery of cargos necessary for axoneme elongation.
    1. Neuroscience

    Wireless recording from unrestrained monkeys reveals motor goal encoding beyond immediate reach in frontoparietal cortex

    Michael Berger, Naubahar Shahryar Agha, Alexander Gail
    The novel Reach Cage allows neurophysiology studies of structured behavior with unrestrained Rhesus macaques showing that the frontoparietal reach network is selective for reach goals outside the immediately reachable space.
    1. Neuroscience

    Slow presynaptic mechanisms that mediate adaptation in the olfactory pathway of Drosophila

    Carlotta Martelli, André Fiala
    Slow presynaptic depression in olfactory receptor neurons rescales combinatorial odor representations in postsynaptic neurons and mediates the encoding of stimulus mean and variance.
    1. Microbiology and Infectious Disease

    Genetic and chemical validation of Plasmodium falciparum aminopeptidase PfA-M17 as a drug target in the hemoglobin digestion pathway

    Rebecca CS Edgar, Ghizal Siddiqui ... Tania F de Koning-Ward
    Plasmodium falciparum aminopeptidase PfA-M17 is essential to parasite survival and plays a role in hemoglobin digestion, providing a rationale for further development of inhibitors against this enzyme.
    1. Ecology

    Dynamic metabolic exchange governs a marine algal-bacterial interaction

    Einat Segev, Thomas P Wyche ... Roberto Kolter
    Physical and chemical interactions with bacteria influence the life and death of Emiliania huxleyi, a bloom-forming micro-alga important in global biogeochemical cycles.
    1. Neuroscience

    A neural circuit mechanism for regulating vocal variability during song learning in zebra finches

    Jonathan Garst-Orozco, Baktash Babadi, Bence P Ölveczky
    By demonstrating song learning-related synaptic strengthening and pruning in the vocal control circuits of songbirds, and showing how such changes can reduce the sensitivity of the circuit to ‘noisy’ inputs, a simple neural circuit mechanism for regulating motor variability during motor skill learning is identified.
    1. Developmental Biology
    2. Evolutionary Biology

    Decoupling from yolk sac is required for extraembryonic tissue spreading in the scuttle fly Megaselia abdita

    Francesca Caroti, Everardo González Avalos ... Steffen Lemke
    Extraembryonic tissue spreading in the scuttle fly Megaselia abdita requires mechanical decoupling from the underlying yolk sac.
    1. Cell Biology
    2. Physics of Living Systems

    A mechano-osmotic feedback couples cell volume to the rate of cell deformation

    Larisa Venkova, Amit Singh Vishen ... Matthieu Piel
    Whether deforming cells behave as elastic balls (deforming at constant volume) or as sponges (loosing volume as they deform) depends on how fast they change their shape, because the cell volume depends on the tension of the plasma membrane.
    1. Neuroscience

    Visualizing synaptic plasticity in vivo by large-scale imaging of endogenous AMPA receptors

    Austin R Graves, Richard H Roth ... Richard L Huganir
    A knockin mouse line was made to label endogenous AMPA receptors, enabling direct observation of synaptic plasticity in behaving animals with single-synapse resolution across the entire brain.
    1. Neuroscience

    Homeostatic control of deep sleep and molecular correlates of sleep pressure in Drosophila

    Budhaditya Chowdhury, Lakshman Abhilash ... Orie Shafer
    Controlling for the effects of mechanical stimulation during sleep deprivation reveals substantial multi-cycle sleep rebound in Drosophila and reveals serotonin as a potential sleep substance in the fly brain.

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