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2,032 results found
    1. Neuroscience

    Extracellular space preservation aids the connectomic analysis of neural circuits

    Marta Pallotto et al.
    Automated segmentation of neurons and identification of synapses in electron micrographs is significantly improved by using simple modifications to chemical fixation protocols that preserve extracellular space in the brain.
    1. Developmental Biology
    2. Neuroscience

    Purinergic signaling in cochlear supporting cells reduces hair cell excitability by increasing the extracellular space

    Travis A Babola et al.
    Supporting cells in the cochlea change their shape in response to purinergic receptor activation, which influences hair cell excitability by altering potassium redistribution in the extracellular space.
    1. Neuroscience

    Experience-dependent shaping of hippocampal CA1 intracellular activity in novel and familiar environments

    Jeremy D Cohen et al.
    Comparison of the intracellular activity of hippocampal neurons in novel and familiar environments reveals experience-dependent changes in inputs underlying the formation of stable representations of space.
    1. Neuroscience

    Test of the 'glymphatic' hypothesis demonstrates diffusive and aquaporin-4-independent solute transport in rodent brain parenchyma

    Alex J Smith et al.
    Solute movement in brain extracellular space is determined by solute diffusion, and does not depend on convection or aquaporin-4 expression as predicted by the glymphatic mechanism.
    1. Neuroscience

    Ultrastructural comparison of dendritic spine morphology preserved with cryo and chemical fixation

    Hiromi Tamada et al.
    Cryo preservation of brain tissue reveals dendritic spines with thinner necks compared to those prepared with chemical fixation.
    1. Microbiology and Infectious Disease

    Mechanisms of virus dissemination in bone marrow of HIV-1–infected humanized BLT mice

    Mark S Ladinsky et al.
    Large-volume light microscopy combined with higher-resolution electron tomography revealed the spatial distribution of virus-producing cells and highlighted mechanisms of HIV-1 dissemination in bone marrow from a small animal model.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Mechanical force induces mitochondrial fission

    Sebastian Carsten Johannes Helle et al.
    Mechanically stimulating mitochondria causes them to divide via the recruitment of the mitochondrial fission machinery to the mechanically strained site, showing that intracellular organelles can be mechanoresponsive.
    1. Neuroscience

    Ultrastructural analysis of adult mouse neocortex comparing aldehyde perfusion with cryo fixation

    Natalya Korogod et al.
    Snap-freezing of brain tissue reveals its true structure-showing that cells are less squashed together, and the connections between neurons are less enclosed than previously thought.
    1. Physics of Living Systems

    Diffusion vs. direct transport in the precision of morphogen readout

    Sean Fancher, Andrew Mugler
    A theory predicts whether diffusion or direct transport establishes a more precise morphogen profile, and this prediction explains data from a wide variety of morphogens in two different organisms.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Regulating G protein-coupled receptors by topological inversion

    Bray Denard et al.
    Multiple biochemical assays show that the topology of CCR5 and possibly other GPCRs may be inverted by ceramide or other sphingolipids through the process of regulated alternative translocation.

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