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    1. Cell Biology
    2. Developmental Biology

    Organ sculpting by patterned extracellular matrix stiffness

    Justin Crest et al.
    Direct measurement of finely patterned mechanical properties in a native basement membrane demonstrate how force asymmetries arising from this extracellular matrix, rather than from cells, can precisely sculpt a tissue.
    1. Plant Biology

    A lectin receptor kinase as a potential sensor for extracellular nicotinamide adenine dinucleotide in Arabidopsis thaliana

    Chenggang Wang et al.
    Genetic and biochemical analyses demonstrate that cell-surface lectin receptors can potentially function as extracellular NAD+-binding receptors and provide direct evidence for extracellular NAD+ being a bona fide endogenous signaling molecule in plants.
    1. Cell Biology
    2. Human Biology and Medicine

    Extracellular matrix signatures of human mammary carcinoma identify novel metastasis promoters

    Alexandra Naba et al.
    Many extracellular matrix proteins that are up-regulated during breast tumor progression enhance metastasis, and some are prognostic indicators of poor survival.
    1. Cell Biology
    2. Immunology and Inflammation

    Diverse stimuli engage different neutrophil extracellular trap pathways

    Elaine F Kenny et al.
    NETs induction, a central component of the innate immune response, utilises assorted signalling pathways as demonstrated through the analysis of healthy and patient neutrophils treated with five distinct stimuli.
    1. Cell Biology

    Genome-wide interrogation of extracellular vesicle biology using barcoded miRNAs

    Albert Lu et al.
    A screen using artificially barcoded, exosomal microRNAs, paired with CRISPR guide RNAs, helped identify new players in multivesicular endosome exocytosis and a role for Wnt signaling.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Sequestration of host metabolism by an intracellular pathogen

    Lena Gehre et al.
    The bacterium Chlamydia trachomatis, a human pathogen, hijacks its host’s energy supplies by using the parasitophorous vacuole as a glycogen synthesis and storage compartment.
    1. Biochemistry and Chemical Biology

    A secretory kinase complex regulates extracellular protein phosphorylation

    Jixin Cui et al.
    A pseudokinase in the secretory pathway, Fam20A, activates the real Golgi casein kinase, Fam20C, via a unique mechanism that is lost in human diseases.
    1. Neuroscience

    Dystroglycan is a scaffold for extracellular axon guidance decisions

    L Bailey Lindenmaier et al.
    Dystroglycan interacts with multiple partners, including the transmembrane receptor Celsr3, to regulate axon tract formation throughout the developing nervous system.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Control of AMPA receptor activity by the extracellular loops of auxiliary proteins

    Irene Riva et al.
    Glutamate receptor auxiliary proteins exert their effects on receptor gating through two divergent extracellular loops, explaining subunit specificity and allowing the construction of null versions that form complexes normally but do not modify receptor gating.
    1. Developmental Biology
    2. Neuroscience

    Purinergic signaling in cochlear supporting cells reduces hair cell excitability by increasing the extracellular space

    Travis A Babola et al.
    Supporting cells in the cochlea change their shape in response to purinergic receptor activation, which influences hair cell excitability by altering potassium redistribution in the extracellular space.