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    1. Stem Cells and Regenerative Medicine

    Transgenerational dynamics of rDNA copy number in Drosophila male germline stem cells

    Kevin L Lu, Jonathan O Nelson ... Yukiko M Yamashita
    rDNA copy number is shown to dynamically change during aging and through generations, and is actively maintained in male germline of Drosophila.
    1. Cell Biology

    Heat stress promotes longevity in budding yeast by relaxing the confinement of age-promoting factors in the mother cell

    Sandro Baldi, Alessio Bolognesi ... Yves Barral
    To promote longevity under heat stress shares yeast aging factors with progeny through a down-regulation of the diffusion barrier in the membranes between the mitotic cells.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Sir2 phosphorylation through cAMP-PKA and CK2 signaling inhibits the lifespan extension activity of Sir2 in yeast

    Woo Kyu Kang, Yeong Hyeock Kim ... Jeong-Yoon Kim
    The deacetylase Sir2 fine-tunes transcription of PMA1 and other aging related genes in a cAMP-PKA and CK2 signaling dependent manner.
    1. Cell Biology

    Role of SAGA in the asymmetric segregation of DNA circles during yeast ageing

    Annina Denoth-Lippuner, Marek Konrad Krzyzanowski ... Yves Barral
    The SAGA complex binds non-chromosomal DNA circles and prevents their spreading by attaching them to nuclear pores, thereby leading to the concomitant accumulation of DNA circles and pores in ageing yeast mother cells.
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