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Activation of a DNA-damage cell cycle checkpoint during aging causes genome instability and senescence in yeast mother cells.

A meiotic nuclear remodeling event mediates cellular rejuvenation through elimination of senescence factors.

Acetylation of nuclear basket components, following their interaction with accumulating extrachromosomal DNA circles, drives the reorganization of nuclear pore complexes and the loss of cellular viability associated with replicative ageing.

To promote longevity under heat stress shares yeast aging factors with progeny through a down-regulation of the diffusion barrier in the membranes between the mitotic cells.