20 results found
    1. Cancer Biology

    Protein phase separation and its role in tumorigenesis

    Shan Jiang et al.
    The current understanding of phase separation is summarized and its emerging roles in cancer are discussed in detail.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Soluble collectin-12 mediates C3-independent docking of properdin that activates the alternative pathway of complement

    Jie Zhang et al.
    A systematic set of experiments reveals how properdin specifically directs AP activation independently of primary C3 deposition additionally as an alternative convertase stabilizer, thus revising immune machinery of complement activation.
    1. Genetics and Genomics

    A regulatory pathway that selectively up-regulates elongasome function in the absence of class A PBPs

    Yesha Patel et al.
    Balanced peptidoglycan synthesis requires regulators, including sigma-I and WalKR, that coordinate the diffusive action of class A PBPs and the directional motion of the MreB-directed elongasome.
    1. Structural Biology and Molecular Biophysics

    Structure of MlaFB uncovers novel mechanisms of ABC transporter regulation

    Ljuvica R Kolich et al.
    Structure of MlaFB reveals how a small binding protein and the C-terminal tail on an ATPase subunit work together to regulate the assembly and function of an ABC transporter.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Flotillin-mediated membrane fluidity controls peptidoglycan synthesis and MreB movement

    Aleksandra Zielińska et al.
    Correct cell wall synthesis in bacteria depends on flotillin-mediated membrane fluidity.
    1. Neuroscience

    A role for CIM6P/IGF2 receptor in memory consolidation and enhancement

    Xiao-Wen Yu et al.
    Cation-independent-mannose-6-phosphate-receptor, or insulin-like-growth-factor-2-receptor (CIM6P/IGF2R) expressed in the hippocampus controls the protein metabolism regulated by learning and required for memory consolidation, and is also a key mechanism for memory enhancement.
    1. Cell Biology
    2. Developmental Biology

    HIPK4 is essential for murine spermiogenesis

    J Aaron Crapster et al.
    HIPK4 is a male germ cell-enriched kinase that regulates cytoskeletal rearrangements in spermatids during spermiogenesis and is required for male fertility in mice.
    1. Developmental Biology

    Endothelial EphB4 maintains vascular integrity and transport function in adult heart

    Guillermo Luxán et al.
    EphB4 maintains critical functional properties of the adult cardiac vasculature, namely mechanical resistance and fatty acid transport capability, and thereby prevents dilated cardiomyopathy-like defects.
    1. Microbiology and Infectious Disease

    Transcriptome dynamics of the Myxococcus xanthus multicellular developmental program

    José Muñoz-Dorado et al.
    Investigation of global gene expression profiles during formation of the Myxococcus xanthus specialized biofilm reveals a genetic regulatory network that coordinates cell motility, differentiation, and secondary metabolite production.
    1. Microbiology and Infectious Disease

    CCL2 mobilizes ALIX to facilitate Gag-p6 mediated HIV-1 virion release

    David O Ajasin et al.
    Effect of CCL2 on HIV-1 replication is mediated by mobilization of ALIX from F-actin leading to enhanced virion release and improved fitness and this requires the Gag late motif, LYPX.

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