20 results found
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Soluble collectin-12 mediates C3-independent docking of properdin that activates the alternative pathway of complement

    Jie Zhang et al.
    A systematic set of experiments reveals how properdin specifically directs AP activation independently of primary C3 deposition additionally as an alternative convertase stabilizer, thus revising immune machinery of complement activation.
    1. Microbiology and Infectious Disease

    Transcriptome dynamics of the Myxococcus xanthus multicellular developmental program

    José Muñoz-Dorado et al.
    Investigation of global gene expression profiles during formation of the Myxococcus xanthus specialized biofilm reveals a genetic regulatory network that coordinates cell motility, differentiation, and secondary metabolite production.
    1. Physics of Living Systems
    2. Computational and Systems Biology

    Overall energy conversion efficiency of a photosynthetic vesicle

    Melih Sener et al.
    The overall energy conversion efficiency is calculated for a bacterial vesicle that harvests solar energy for ATP production on the basis of an atomic-detail structural model.
    1. Neuroscience

    A role for CIM6P/IGF2 receptor in memory consolidation and enhancement

    Xiao-Wen Yu et al.
    Cation-independent-mannose-6-phosphate-receptor, or insulin-like-growth-factor-2-receptor (CIM6P/IGF2R) expressed in the hippocampus controls the protein metabolism regulated by learning and required for memory consolidation, and is also a key mechanism for memory enhancement.
    1. Cell Biology

    Megakaryocyte emperipolesis mediates membrane transfer from intracytoplasmic neutrophils to platelets

    Pierre Cunin et al.
    In a novel cell-in-cell interaction termed emperipolesis, neutrophils routinely transit through the cytoplasm of bone marrow megakaryocytes to pass surface membrane to newly-generated hybrid platelets.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Regulation of signaling directionality revealed by 3D snapshots of a kinase:regulator complex in action

    Felipe Trajtenberg et al.
    The molecular mechanism of switching between phosphotransferase- and phosphatase-competent states in histidine-kinases has been uncovered, through direct crystallographic observation of bona fide complexes between a histidine-kinase and its response regulator from Bacillus subtilise.
    1. Genetics and Genomics

    A regulatory pathway that selectively up-regulates elongasome function in the absence of class A PBPs

    Yesha Patel et al.
    Balanced peptidoglycan synthesis requires regulators, including sigma-I and WalKR, that coordinate the diffusive action of class A PBPs and the directional motion of the MreB-directed elongasome.
    1. Microbiology and Infectious Disease

    Plasticity of Escherichia coli cell wall metabolism promotes fitness and antibiotic resistance across environmental conditions

    Elizabeth A Mueller et al.
    Environmental specialization of bacterial cell wall synthases influences intrinsic resistance to cell wall active antibiotics.
    1. Immunology and Inflammation

    Long-term antigen exposure irreversibly modifies metabolic requirements for T cell function

    Marie Bettonville et al.
    Long-term exposure to recipient's alloantigens promotes major metabolic defects in T cells that are independent of PD-1-mediated regulation.
    1. Cancer Biology

    Protein phase separation and its role in tumorigenesis

    Shan Jiang et al.
    The current understanding of phase separation is summarized and its emerging roles in cancer are discussed in detail.

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