63 results found
    1. Immunology and Inflammation

    C/EBPδ drives interactions between human MAIT cells and endothelial cells that are important for extravasation

    Chang Hoon Lee et al.
    The bZIP transcription factor C/EBPδ enhances expression both of selectin ligands and the chemokine receptor CCR6 on human mucosal-associated invariant T cells, supporting their efficient extravasation into inflamed tissue.
    1. Immunology and Inflammation

    Blood flow guides sequential support of neutrophil arrest and diapedesis by PILR-β1 and PILR-α

    Yu-Tung Li et al.
    Blood flow-driven shear forces guide the sequential signaling of two antagonistic paired receptors, a critical bi-facet step that first supports leukocyte docking, then initiates transmigration through endothelium.
    1. Cancer Biology
    2. Physics of Living Systems

    Dissecting the immunosuppressive tumor microenvironments in Glioblastoma-on-a-Chip for optimized PD-1 immunotherapy

    Xin Cui et al.
    A biomimetic and patient-specific Glioblastoma-on-a-Chip microphysiological system provides an avenue for personalized screening of PD-1 immunotherapy and novel combinational therapies that maximize therapeutic outcomes in Glioblastoma patients.
    1. Cell Biology
    2. Immunology and Inflammation

    Endothelial junctional membrane protrusions serve as hotspots for neutrophil transmigration

    Janine JG Arts et al.
    Neutrophils use dorsal membrane protrusions of endothelial cells to cross the vascular wall.
    1. Developmental Biology

    Suppression of transcytosis regulates zebrafish blood-brain barrier function

    Natasha M O'Brown et al.
    The zebrafish has been established as a genetic and molecular model for the blood-brain barrier.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    The skin is a significant but overlooked anatomical reservoir for vector-borne African trypanosomes

    Paul Capewell et al.
    African trypanosomes residing within the skin of infected humans represent an important yet overlooked transmissible parasite population that may thwart efforts to eliminate African sleeping sickness.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    ARID1A loss in adult hepatocytes activates β-catenin-mediated erythropoietin transcription

    Rozenn Riou et al.
    A chromatin remodeling factor cooperates with Wnt signaling pathway to transcribe erythropoietin in the adult liver, inducing its secretion and a dramatic erythropoiesis in the spleen.
    1. Neuroscience

    Apolipoprotein M-bound sphingosine-1-phosphate regulates blood–brain barrier paracellular permeability and transcytosis

    Mette Mathiesen Janiurek et al.
    Shortage of blood-borne apolipoprotein-M–bound sphingosine-1-phosphate, which accompanies various brain disorders, causes paracellular leak and increase in transcytosis at the blood–brain barrier, which can be reversed, thus is of clinical relevance.
    1. Cell Biology

    Vascular permeability in retinopathy is regulated by VEGFR2 Y949 signaling to VE-cadherin

    Ross O Smith et al.
    Pathological vessel leakage in mouse retinopathy models depends on VE-cadherin Y685 phosphorylation status, which in turn is regulated by a signaling cascade originating with VEGFR2 Y949 phosphorylation.
    1. Structural Biology and Molecular Biophysics
    2. Cancer Biology

    A bulky glycocalyx fosters metastasis formation by promoting G1 cell cycle progression

    Elliot C Woods et al.
    Mucins, long associated with cancer aggression, remodel the cancer glycocalyx in a way that promotes proliferation in the metastatic site by enhancing integrin-mediated adhesion and thus driving cell cycle progression.

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