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  1. Nuclear pore assembly proceeds by an inside-out extrusion of the nuclear envelope

    Shotaro Otsuka et al.
    Nuclear pores assemble asymmetrically, by an inside-out evagination of the inner nuclear membrane that grows in diameter and depth until it fuses with the flat outer nuclear membrane.
    1. Cell Biology

    Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans

    Yanan Sun et al.
    Cell biological and genetic studies reveal age-associated alterations of lysosomes and modulation of lysosomal activity by longevity pathways.
    1. Biochemistry and Chemical Biology

    Crystallographic observation of nonenzymatic RNA primer extension

    Wen Zhang et al.
    Time resolved crystal structures reveal the binding of activated monomers to the template, followed by generation of the imidazolium-bridged dinucleotide intermediate, and finally formation of a phosphodiester bond between the primer and the adjacent monomer.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Science Forum: Addressing selective reporting of experiments through predefined exclusion criteria

    Kleber Neves, Olavo B Amaral
    Researchers should define in advance the criteria for excluding the results of experiments that 'did not work' from articles.
    1. Cell Biology

    SUMO peptidase ULP-4 regulates mitochondrial UPR-mediated innate immunity and lifespan extension

    Kaiyu Gao et al.
    SUMOylation regulates mitochondrial UPR signaling through modulation of transcription factors DVE-1 and ATFS-1.
    1. Cell Biology
    2. Developmental Biology

    Anisotropic organization of circumferential actomyosin characterizes hematopoietic stem cells emergence in the zebrafish

    Mylene Lancino et al.
    Emergence of hematopoietic stem cells from an aortic component is a unique phenomenon of cell extrusion, with no equivalent in cell biology, and which is adapted to environmental constraints exerted by endothelial cells and hemodynamics forces.
    1. Developmental Biology

    The flow responsive transcription factor Klf2 is required for myocardial wall integrity by modulating Fgf signaling

    Seyed Javad Rasouli et al.
    Endocardial Klf2 regulates cardiomyocyte adhesion and myocardial wall integrity by modulating FGF signaling in zebrafish.
    1. Biochemistry and Chemical Biology

    Efficient analysis of mammalian polysomes in cells and tissues using Ribo Mega-SEC

    Harunori Yoshikawa et al.
    Translationally active polysomes from mammalian cells/tissues are successfully separated with rapidity, high efficiency and exceptional reproducibility by a SEC-based approach, an accessible alternative to the conventional sucrose density gradient analysis.
    1. Cell Biology
    2. Developmental Biology

    Spatial and temporal analysis of PCP protein dynamics during neural tube closure

    Mitchell T Butler, John B Wallingford
    Planar cell polarity proteins display dynamic spatial and temporal patterns of enrichment that tightly correlate with myosin-dependent cell behaviors during neural tube closure.
    1. Computational and Systems Biology
    2. Developmental Biology

    Vertex sliding drives intercalation by radial coupling of adhesion and actomyosin networks during Drosophila germband extension

    Timothy E Vanderleest et al.
    Tricellular vertices possess sliding behaviors that harness radial forces and drive cell shape changes and intercalation in an epithelial tissue.