2,497 results found
    1. Cell Biology
    2. Neuroscience

    Aberrant information transfer interferes with functional axon regeneration

    Chen Ding, Marc Hammarlund
    Defects in synapse regeneration limit functional circuit recovery after nerve injury by misdirecting information via ectopic dendritic synapses, and also by functional and molecular deficits in reformed axonal synapses.
    1. Neuroscience

    Fast-backward replay of sequentially memorized items in humans

    Qiaoli Huang et al.
    Serially remembered items are successively reactivated during memory maintenance in the human brain, and replay profiles, temporally compressed and reverse in order, are associated with recency effect in behavioral performance.
    1. Microbiology and Infectious Disease

    Maturing Mycobacterium smegmatis peptidoglycan requires non-canonical crosslinks to maintain shape

    Catherine Baranowski et al.
    Polar elongating mycobacteria (Mycobacterium smegmatis) require specific cell wall chemistries, those catalyzed by targets of critical antibiotics, to maintain rod shape at aging sites of the bacillus.
    1. Computational and Systems Biology
    2. Developmental Biology

    Tuned polymerization of the transcription factor Yan limits off-DNA sequestration to confer context-specific repression

    C Matthew Hope et al.
    Tuned protein–protein interaction affinity optimizes the repressive function of the ETS family transcription factor Yan in order to contribute specificity and robustness to cell fate specification in the developing Drosophila eye.
    1. Neuroscience

    Sensory experience inversely regulates feedforward and feedback excitation-inhibition ratio in rodent visual cortex

    Nathaniel J Miska et al.
    Sensory deprivation suppresses cortical responsiveness through a selective remodeling of excitatory and inhibitory microcircuit motifs, by simultaneously amplifying feedforward and suppressing feedback excitation.
    1. Developmental Biology
    2. Neuroscience

    Dlk1-Dio3 locus-derived lncRNAs perpetuate postmitotic motor neuron cell fate and subtype identity

    Ya-Ping Yen et al.
    LncRNAs are important to stabilize postmitotic cell fate of spinal motor neurons.
    1. Computational and Systems Biology

    Trajectories of childhood immune development and respiratory health relevant to asthma and allergy

    Howard HF Tang et al.
    Unsupervised cluster analysis identified similar groups of children in different cohorts, with distinct developmental patterns of immunorespiratory health, asthma and allergy.
    1. Cancer Biology

    Loss of p53 suppresses replication-stress-induced DNA breakage in G1/S checkpoint deficient cells

    Bente Benedict et al.
    During tumorigenesis loss of p53 not only abrogates cell cycle arrest and apoptosis, but also suppresses the induction of replication-stress-induced DNA double-stranded breaks.
    1. Neuroscience

    Light-dependent pathways for dopaminergic amacrine cell development and function

    Teona Munteanu et al.
    Rods, not ipRGCs, are the major retinal photoreceptor impacting development of dopaminergic signaling in the retina.
    1. Neuroscience

    Range, routing and kinetics of rod signaling in primate retina

    William N Grimes et al.
    Signals from primate rod photoreceptors do not exhibit the light-level-dependent routing through parallel retinal circuits observed in rodents and often invoked in interpreting psychophysical experiments.

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