Jeremy M Trott, Ann N Hoffman ... Michael S Fanselow
When conducting fear conditioning in mice, cue-elicited activity bursts are primarily a result of nonassociative processes, and freezing behavior remains the best index for associative learning.
Michael A Gaffield, Britton A Sauerbrei, Jason M Christie
The activity of cerebellar Purkinje cells both represents and participates in organizing the temporal structure of a periodically performed motor action.
Soo Ji Baek, Jin Sung Park ... Keiko Tanaka-Yamamoto
Long-term chemogenetic manipulation of specific cerebellar pathway involving ventral tegmental area revealed a critical role of the pathway as a proactive mediator of the stress-dependent development of depression-like behaviors.
Cholecystokinin-positive neural projection from entorhinal cortex to lateral amygdala modulates the long-term potentiation of auditory-evoked potential in lateral amygdala and underlies the formation of trace fear memory.
CA1 and PFC bridge the temporal gap between cue and reward delivery during trace conditioning according to different underlying coding principles and task-related activity is reactivated during awake Sharp-Wave Ripples.
Peter Zatka-Haas, Nicholas A Steinmetz ... Kenneth D Harris
Local sensory signals in visual and frontal cortex play a causal role in task performance, while widespread dorsal cortical signals correlating with movement reflect processes that do not.
Katarzyna Kita, Catarina Albergaria ... Igor Delvendahl
GluA4-containing AMPA receptors are required for effective excitation of cerebellar granule cells and enable expansion coding and associative learning.
Different Purkinje cell subpopulations show distinct developmental profiles of physiological activity, climbing fiber inputs and axonal and dendritic morphology, matching different timelines of cerebellum-dependent behaviors.
Large-scale imaging analysis of CA1 reveals that distinct neural networks are involved in trace conditioning versus extinction learning, shedding light on how the hippocampus encodes different types of memory.
Two-photon in vivo calcium imaging reveals short time-scale, synchronous and sparse population activity in dentate gyrus that replays place-related information, and is important for formation of dentate-dependent spatial memory.
