41 results found
    1. Computational and Systems Biology
    2. Neuroscience

    Probable nature of higher-dimensional symmetries underlying mammalian grid-cell activity patterns

    Alexander Mathis et al.
    Mathematical analysis confirms that hexagonal patterns of neuronal activity are the most efficient means for the brain to represent 2D space, and predicts that activity patterns resembling densely packed lattices are optimal for representing 3D space.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Self-organised segregation of bacterial chromosomal origins

    Andreas Hofmann et al.
    The self-organising condensin MukBEF positions chromosomal origins in Escherichia coli..
    1. Cell Biology

    Mapping the dynamics of force transduction at cell–cell junctions of epithelial clusters

    Mei Rosa Ng et al.
    The integrated quantification of spontaneous dynamic cell-cell force transmissions at both multi-cellular and subcellular scales enables spatiotemporal correlations of stress distribution with biomolecules in small cell clusters.
    1. Neuroscience

    The self-organization of grid cells in 3D

    Federico Stella, Alessandro Treves
    A computational model for the formation of neural networks of grid cells in virtual bats suggests that the highly ordered networks presumed to support spatial navigation in two dimensions cannot be routinely established in three-dimensional space.
    1. Cell Biology
    2. Computational and Systems Biology

    Kinesin-4 KIF21B limits microtubule growth to allow rapid centrosome polarization in T cells

    Peter Jan Hooikaas et al.
    Kinesin-4 KIF21B promotes rapid reorientation of the microtubule network during formation of immunological synapse in T cells by acting as a pausing and catastrophe-inducing factor that keeps microtubules short.
    1. Computational and Systems Biology

    A molecular view on the escape of lipoplexed DNA from the endosome

    Bart MH Bruininks et al.
    The molecular insight in lipoplex transfection mechanisms helps in the development of efficient and affordable gene delivery systems.
    1. Neuroscience

    A principle of economy predicts the functional architecture of grid cells

    Xue-Xin Wei et al.
    Mathematical modeling suggests that grid cells in the rodent brain use fundamental principles of number theory to maximize the efficiency of spatial mapping, enabling animals to accurately encode their location with as few neurons as possible.
    1. Stem Cells and Regenerative Medicine
    2. Neuroscience

    Adult axolotls can regenerate original neuronal diversity in response to brain injury

    Ryoji Amamoto et al.
    Upon injury, the regeneration of the adult axolotl brain rebuilds neuronal diversity, but alters the original long-distance circuitry and tissue architecture.
    1. Structural Biology and Molecular Biophysics

    Mechanism of completion of peptidyltransferase centre assembly in eukaryotes

    Vasileios Kargas et al.
    Cryo-EM reveals how the central functional site of the ribosome is assembled and provides a framework to interpret the consequences of mutations linked to leukaemia-associated ribosomopathies.
    1. Plant Biology

    A multifaceted analysis reveals two distinct phases of chloroplast biogenesis during de-etiolation in Arabidopsis

    Rosa Pipitone et al.
    Serial-Block-Face Scanning Electron Microscopy (SBF-SEM) associated with biomolecular analysis show that chloroplast differentiation proceeds by distinct ‘structure establishment’ and ‘chloroplast proliferation’ phases, each with differential protein and lipid regulation.

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