29 results found
    1. Computational and Systems Biology
    2. Neuroscience

    Probable nature of higher-dimensional symmetries underlying mammalian grid-cell activity patterns

    Alexander Mathis et al.
    Mathematical analysis confirms that hexagonal patterns of neuronal activity are the most efficient means for the brain to represent 2D space, and predicts that activity patterns resembling densely packed lattices are optimal for representing 3D space.
    1. Stem Cells and Regenerative Medicine
    2. Neuroscience

    Adult axolotls can regenerate original neuronal diversity in response to brain injury

    Ryoji Amamoto et al.
    Upon injury, the regeneration of the adult axolotl brain rebuilds neuronal diversity, but alters the original long-distance circuitry and tissue architecture.
    1. Neuroscience

    A principle of economy predicts the functional architecture of grid cells

    Xue-Xin Wei et al.
    Mathematical modeling suggests that grid cells in the rodent brain use fundamental principles of number theory to maximize the efficiency of spatial mapping, enabling animals to accurately encode their location with as few neurons as possible.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Symmetry broken and rebroken during the ATP hydrolysis cycle of the mitochondrial Hsp90 TRAP1

    Daniel Elnatan et al.
    A flip of the dimer asymmetry following the first ATP hydrolysis provides a mechanistic model for client remodeling by the mitochondrial Hsp90, TRAP1.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Molecular basis of sidekick-mediated cell-cell adhesion and specificity

    Kerry M Goodman et al.
    Crystal structures of synaptic recognition molecules Sidekick-1 and -2 reveal a single homodimer interaction mode responsible for both cell-cell recognition and cis-clustering, suggesting that competition between cis and trans interactions may be critical to specificity.
    1. Structural Biology and Molecular Biophysics

    Mechanism of completion of peptidyltransferase centre assembly in eukaryotes

    Vasileios Kargas et al.
    Cryo-EM reveals how the central functional site of the ribosome is assembled and provides a framework to interpret the consequences of mutations linked to leukaemia-associated ribosomopathies.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Visualizing the functional architecture of the endocytic machinery

    Andrea Picco et al.
    A combination of light and electron microscopy data provide new insights into the dynamic architecture and the function of the endocytic protein machinery in relation to membrane shape changes in vivo.
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    A dynamic mechanism for allosteric activation of Aurora kinase A by activation loop phosphorylation

    Emily F Ruff et al.
    Phosphorylation of Aurora A does not trigger a population shift to the active state as previously thought, but instead switches the kinase on by tuning the structure and dynamics of a dynamically sampled subpopulation.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Self-organised segregation of bacterial chromosomal origins

    Andreas Hofmann et al.
    The self-organising condensin MukBEF positions chromosomal origins in Escherichia coli..
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Kinesin motility is driven by subdomain dynamics

    Wonmuk Hwang et al.
    The motor protein kinesin utilizes its fuel molecule by active and concerted motions of its subdomains, while it rapidly interacts with the microtubule track by forming a wet and dynamic interface.

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