391 results found
    1. Neuroscience

    Ventral hippocampal projections to the medial prefrontal cortex regulate social memory

    Mary L Phillips, Holly Anne Robinson, Lucas Pozzo-Miller
    Input from the ventral hippocampus to the medial prefrontal cortex regulates social memory in wild type mice and atypically-strengthened input causes social memory dysfunction in Rett syndrome mice.
    1. Neuroscience

    Emotional learning retroactively promotes memory integration through rapid neural reactivation and reorganization

    Yannan Zhu, Yimeng Zeng ... Shaozheng Qin
    Emotional learning retroactively promotes memory integration for previously neutral events into episodic memory to foster future event predictions, through rapidly stimulating trial-specific reactivation of overlapping memory traces and reorganization of associated memories among the amygdala, hippocampal, and neocortical circuits.
    1. Neuroscience

    A subcortical circuit linking the cerebellum to the basal ganglia engaged in vocal learning

    Ludivine Pidoux, Pascale Le Blanc ... Arthur Leblois
    The cerebellum sends a functional input to the song-related basal ganglia via the thalamus in songbirds that can modify premotor activity, and it participates to song learning in juvenile birds.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    FBXL19 recruits CDK-Mediator to CpG islands of developmental genes priming them for activation during lineage commitment

    Emilia Dimitrova, Takashi Kondo ... Robert J Klose
    The ZF-CxxC protein FBXL19 recruits kinase-associated Mediator to CpG islands of silent developmental genes in embryonic stem cells, which primes these genes for activation during differentiation and is required for embryonic development.
    1. Developmental Biology
    2. Neuroscience

    Analogous mechanism regulating formation of neocortical basal radial glia and cerebellar Bergmann glia

    Xin Heng, Qiuxia Guo ... James YH Li
    Genome-wide transcriptional profiling and genetic analyses reveal conserved mechanisms underlying the generation of neocortical basal radial glia and cerebellar Bergmann glia.
    1. Genetics and Genomics

    Association of genetic variation in COL11A1 with adolescent idiopathic scoliosis

    Hao Yu, Anas M Khanshour ... Carol A Wise
    Variation in type XI collagen alters estrogen-dependent signaling in the extracellular matrix and is identified as a genetic risk factor for adolescent idiopathic scoliosis, a common childhood deformity.
    1. Neuroscience

    Neural activity tracking identity and confidence in social information

    Nadescha Trudel, Patricia L Lockwood ... Marco K Wittmann
    People's confidence in information and their neural correlates in key regions of the social brain are more stable when tracking social advice compared to non-social information.
    1. Developmental Biology
    2. Evolutionary Biology

    A distinct cardiopharyngeal mesoderm genetic hierarchy establishes antero-posterior patterning of esophagus striated muscle

    Glenda Comai, Eglantine Heude ... Shahragim Tajbakhsh
    Tbx1-Isl1-Met defines a unique genetic hierarchy that regulates esophagus myogenesis and patterning in the mouse.
    1. Stem Cells and Regenerative Medicine

    Persistent epigenetic memory impedes rescue of the telomeric phenotype in human ICF iPSCs following DNMT3B correction

    Shir Toubiana, Miriam Gagliardi ... Sara Selig
    Correction of the DNA methyltransferase 3B gene in ICF1 syndrome fails to rescue the abnormal DNA hypomethylation at subtelomeric regions due to accompanied epigenetic abnormalities in these regions.
    1. Computational and Systems Biology
    2. Epidemiology and Global Health

    Associations of four biological age markers with child development: A multi-omic analysis in the European HELIX cohort

    Oliver Robinson, ChungHo E Lau ... Martine Vrijheid
    Among European children, shorter telomere length and older DNA methylation age relative to chronological age were associated with poorer behaviors, while older age, as predicted by a novel immunometabolic clock relative to chronological age, was associated with greater cognitive maturity.

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