During zebrafish embryogenesis, dact1 and dact2 are necessary for axis lengthening and craniofacial morphogenesis, and the protease capn8 is misexpressed in dact1/2 mutants.

Innovative JAGGED1-based therapies show promise for pediatric craniofacial bone loss, potentially overcoming limitations of current treatments with more effective and accessible solutions.

The long mandibles were gradually replaced by more flexible trunks in the evolution of proboscideans.

SNP-editing of human embryonic stem cells reveals cell type specific function of a genetic variant associated with changes in human jaw shape.

Variation in type XI collagen alters estrogen-dependent signaling in the extracellular matrix and is identified as a genetic risk factor for adolescent idiopathic scoliosis, a common childhood deformity.

Spatially distinct ectodermal Wnt and endodermal Shh signals serve to polarize the skate gill skeleton.

Cancer invasion occurs with different molecular and spatial patterns, thin invading strands are associated with mesenchymal cell features, such as low cell-cell adhesion, while broad strands are favoured for lymph node metastasis and require high matrix proteolysis and cell-cell adhesions.

Discoidin domain receptor 2 controls craniofacial morphology by acting in skeletal progenitor cells and chondrocytes to control collagen matrix organization, chondrocyte polarity, and growth.

Genetic lineage tracing reveals the cardiopharyngeal mesoderm as a cellular origin of craniofacial and cardiac lymphatic vessels, which most often affected in lymphatic malformation patients.